Kaya Bulent, Aras Orhan, Bat Orhan, Bulut Nuriye Esen, Memisoglu Kemal
Fatih Sultan Mehmet Training and Research Hospital, Department of General Surgery, Istanbul, Turkey.
Clin Med Insights Pathol. 2012;5:11-4. doi: 10.4137/CPath.S7924. Epub 2012 Mar 29.
Corticosteroids are used in the treatment of many rheumatological diseases including temporal arteritis. The gastrointestinal perforation during corticosteroid treatment is a serious complication. Colon perforation after steroid use was first reported by Beck et al in 1950.1 Although the pathophysiological mechanism is not understood clearly, it is claimed that steroids probably by disturbing the intestinal mucosal barrier, facilitate the intestinal perforation. The long term treatment with corticosteroids increases the risk of colon perforation. We are presenting a patient who was taking corticosteroid due to temporal arteritis for two years and operated with sigmoid diverticular perforation.
皮质类固醇用于治疗包括颞动脉炎在内的多种风湿性疾病。皮质类固醇治疗期间的胃肠道穿孔是一种严重的并发症。1950年,贝克等人首次报道了使用类固醇后发生的结肠穿孔。尽管其病理生理机制尚不清楚,但据称类固醇可能通过干扰肠道黏膜屏障而促使肠道穿孔。长期使用皮质类固醇会增加结肠穿孔的风险。我们报告一例因颞动脉炎服用皮质类固醇两年并因乙状结肠憩室穿孔而接受手术的患者。