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Cancer incidence and mortality in Europe, 2004.2004年欧洲的癌症发病率和死亡率
Ann Oncol. 2005 Mar;16(3):481-8. doi: 10.1093/annonc/mdi098. Epub 2005 Feb 17.
2
Alcohol and cancer.酒精与癌症。
Alcohol Alcohol. 2004 May-Jun;39(3):155-65. doi: 10.1093/alcalc/agh057.
3
Mechanisms of alcohol-induced tissue injury.酒精诱导的组织损伤机制。
Alcohol Clin Exp Res. 2003 Mar;27(3):563-75. doi: 10.1097/01.ALC.0000057946.57330.F7.
4
Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease.酒精、烟草与乳腺癌——对53项流行病学研究的个体数据进行的联合重新分析，其中包括58515名乳腺癌女性患者和95067名未患该病的女性。
Br J Cancer. 2002 Nov 18;87(11):1234-45. doi: 10.1038/sj.bjc.6600596.
5
Alcohol consumption increases the risk of fatal breast cancer (United States).饮酒会增加患致命性乳腺癌的风险（美国）。
Cancer Causes Control. 2001 Dec;12(10):895-902. doi: 10.1023/a:1013737616987.
6
Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study.膳食叶酸摄入量与乳腺癌风险：上海乳腺癌研究结果
Cancer Res. 2001 Oct 1;61(19):7136-41.
7
Effect of ethanol on proliferation and estrogen receptor-alpha expression in human breast cancer cells.乙醇对人乳腺癌细胞增殖及雌激素受体α表达的影响
Cancer Lett. 2001 Apr 26;165(2):131-7. doi: 10.1016/s0304-3835(01)00419-0.
8
Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue. Its potential role in alcohol-promoted mammary cancer.胞质黄嘌呤氧化还原酶介导乙醇在大鼠乳腺组织中生物活化生成乙醛和自由基。其在酒精促发乳腺癌中的潜在作用。
Toxicology. 2001 Mar 7;160(1-3):11-8. doi: 10.1016/s0300-483x(00)00433-9.
9
Can alcohol promote aromatization of androgens to estrogens? A review.酒精能促进雄激素向雌激素的芳香化作用吗？一篇综述。
Alcohol. 2000 Nov;22(3):123-7. doi: 10.1016/s0741-8329(00)00124-5.
10
Stimulation of cell invasion and migration by alcohol in breast cancer cells.酒精对乳腺癌细胞侵袭和迁移的刺激作用。
Biochem Biophys Res Commun. 2000 Jul 5;273(2):448-53. doi: 10.1006/bbrc.2000.2942.

酒精与乳腺癌：作用机制解析

Alcohol and breast cancer: the mechanisms explained.

作者信息

Al-Sader Hassen, Abdul-Jabar Hani, Allawi Zahra, Haba Yasser

机构信息

Department of General Medicine, St Georges Hospital, UK.

出版信息

J Clin Med Res. 2009 Aug;1(3):125-31. doi: 10.4021/jocmr2009.07.1246. Epub 2009 Jul 3.

DOI:10.4021/jocmr2009.07.1246
PMID:22493645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318874/
Abstract

UNLABELLED

Breast cancer is a leading cause of death amongst women, several studies have shown significant association between alcohol consumption and breast cancer. The aim of this overview is to highlight some of the mechanisms by which alcohol consumption could increase the risk of developing breast cancer. Using online Medline search engine, article containing details about mechanisms which explain the link between alcohol and breast cancer were examined. A number of mechanisms were found by which alcohol could increase the risk of breast cancer, alcohol's interaction and effect on oestrogen secretion; number of oestrogen receptors; the generation of acetaldehyde and hydroxyl free radicals; cells migration and metastasis; secretion of IGF1 and interaction with HRT and folate metabolism. In conclusion, it is essential for clinicians to understand these mechanisms and inform patients of the link between alcohol and breast cancer.

KEYWORDS

Breast cancer; Alcohol; Mechanisms.

摘要

未标注

乳腺癌是女性死亡的主要原因之一，多项研究表明饮酒与乳腺癌之间存在显著关联。本综述的目的是强调饮酒可能增加患乳腺癌风险的一些机制。使用在线医学文献数据库检索引擎，对包含解释酒精与乳腺癌之间联系机制细节的文章进行了审查。发现了多种酒精可能增加乳腺癌风险的机制，包括酒精与雌激素分泌的相互作用和影响；雌激素受体的数量；乙醛和羟基自由基的产生；细胞迁移和转移；胰岛素样生长因子1的分泌以及与激素替代疗法和叶酸代谢的相互作用。总之，临床医生必须了解这些机制，并告知患者酒精与乳腺癌之间的联系。

关键词

乳腺癌；酒精；机制