Cupane L, Pugacova N, Berzina D, Cauce V, Gardovska D, Miklaševics E
1Children Clinical University Hospital, Riga, Latvia.
Int J Mol Epidemiol Genet. 2012;3(1):48-55. Epub 2012 Feb 28.
Staphylococcus aureus is a major cause of purulent infections. The spectrum of staphylococcal infections varies from mild superficial to invasive life-threatening diseases due to S. aureus ability to produce a wide range of virulence factors, including toxins. A prospective observational study was conducted in the Children Clinical University Hospital in Riga, Latvia. During a period of sixteen months from November 2006 to March 2008 224 S. aureus isolates were collected. Our study revealed that Panton-Valentine leukocidine (PVL) genes are carried by a high number (75%) of S. aureus isolates recovered from children hospitalised in the Children Clinical University hospital. Most of these isolates were associated with abscesses and other skin and soft tissue infections. Patients with PVL positive invasive infections stayed significantly longer in hospital than patients with PVL negative invasive infections. Clonal distribution of PVL positive S. aureus isolates were closely related, which provides evidence for the wide spread of PVL producing spa type t435 and ST121 staphylococci in community.
金黄色葡萄球菌是化脓性感染的主要病因。由于金黄色葡萄球菌能够产生包括毒素在内的多种毒力因子，其感染谱从轻度浅表感染到危及生命的侵袭性疾病不等。在拉脱维亚里加的儿童临床大学医院进行了一项前瞻性观察研究。在2006年11月至2008年3月的16个月期间，收集了224株金黄色葡萄球菌分离株。我们的研究表明，从儿童临床大学医院住院儿童中分离出的大量（75%）金黄色葡萄球菌携带杀白细胞素（PVL）基因。这些分离株大多与脓肿及其他皮肤和软组织感染有关。PVL阳性侵袭性感染患者的住院时间明显长于PVL阴性侵袭性感染患者。PVL阳性金黄色葡萄球菌分离株的克隆分布密切相关，这为产PVL的spa型t435和ST121葡萄球菌在社区中的广泛传播提供了证据。
