原发性皮肤脓肿主要由携带潘顿-瓦伦丁白细胞毒素的金黄色葡萄球菌引起。
Primary skin abscesses are mainly caused by Panton-Valentine leukocidin-positive Staphylococcus aureus strains.
机构信息
Unité d'Infectiologie-Dermatologie, Hôpital Bonnet, Avenue André Léotard, FR-83700 Fréjus, France.
出版信息
Dermatology. 2009;219(4):299-302. doi: 10.1159/000232391. Epub 2009 Jul 31.
BACKGROUND
The role of Panton-Valentine leukocidin (PVL) in skin and soft-tissue infections is not clear.
OBJECTIVE
Our purpose was to determine the prevalence of PVL gene carriage among Staphylococcus aureus strains isolated from primary and secondary skin abscesses.
METHODS
A prospective study was conducted. From July 2003 to June 2008, S. aureus isolates from skin abscesses were screened for the PVL genes. The abscesses were considered primary if they occurred on previously healthy skin and secondary in all other cases.
RESULTS
Fifty-seven patients presenting with S. aureus skin abscesses were included in the study. The PVL genes were detected in 40 (70%) of the 57 S. aureus isolates. Thirty-eight (92.7%) of the 41 primary skin abscesses were due to PVL-positive strains, compared to only 2 (12.5%) of the 16 secondary skin abscesses (p < 0.001).
CONCLUSIONS
Primary skin abscesses are mainly caused by PVL-positive S. aureus strains.
背景
Panton-Valentine 白细胞素（PVL）在皮肤和软组织感染中的作用尚不清楚。
目的
我们的目的是确定原发性和继发性皮肤脓肿分离的金黄色葡萄球菌菌株中 PVL 基因携带率。
方法
进行了一项前瞻性研究。2003 年 7 月至 2008 年 6 月，筛选了皮肤脓肿分离的金黄色葡萄球菌菌株中是否存在 PVL 基因。如果脓肿发生在先前健康的皮肤上，则将其视为原发性，如果发生在所有其他情况下，则将其视为继发性。
结果
本研究纳入了 57 例金黄色葡萄球菌皮肤脓肿患者。在 57 株金黄色葡萄球菌分离株中，检测到 40 株（70%）携带 PVL 基因。41 例原发性皮肤脓肿中有 38 例（92.7%）是由 PVL 阳性菌株引起的，而 16 例继发性皮肤脓肿中仅有 2 例（12.5%）（p < 0.001）。
结论
原发性皮肤脓肿主要由 PVL 阳性金黄色葡萄球菌菌株引起。
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