Dong Xin-Min, Dong Quan-Sheng, Zhang Xiao-Qiong, Zhu Li
Institute of Acupuncture-Moxibustion and Meridians, Sichuan Academy of Chinese Medical Sciences, Chengdu 610031, China.
Zhongguo Zhen Jiu. 2012 Feb;32(2):149-54.
To discover the central mechanisms of antipyretic effect of moxibustion and its relationship with the acupoint sensor so as to provide the scientific evidence for "the treatment of heat syndrome with moxibustion".
Eighteen New Zealand Rabbits were randomly assigned into three groups, named group A (modeling with intravenous injection of Endotoxin), group B (moxibustion at 40 degrees C after Endotoxin injection) and group C (moxibustion at 48 degrees C after Endotoxin injection), 6 rabbits in each one. The experiment was undergoing in the condition of muscular relaxation and artificial respiration for the animals. The spotlight moxibustion at constant temperature was applied to "Zhiyang" (GV 9). The discharge of heat sensitive neurons (HSNs) at the preoptic region and anterior hypothalamus (POAH) was taken as the index. The impacts of the treatment on HSNs were observed in each group.
Moxibustion had significant antagonism to the pyrogen on its inhibition to the activity of HSNs in the thermotaxic center. As a result, the antipyretic effect was obtained. It is concluded that the effective result of moxibustion is achieved by stimulating polymodal receptors of acupoints.
探讨艾灸退热作用的中枢机制及其与穴位敏化的关系，为“热证用灸”提供科学依据。
将18只新西兰兔随机分为3组，即A组（静脉注射内毒素造模）、B组（内毒素注射后40℃艾灸）和C组（内毒素注射后48℃艾灸），每组6只。实验在动物肌肉松弛和人工呼吸条件下进行。采用恒温 spotlight 艾灸“至阳”（GV 9）。以前视区和下丘脑前部（POAH）热敏神经元（HSNs）的放电为指标，观察各组处理对HSNs的影响。
艾灸对热原抑制体温调节中枢HSNs活动有显著拮抗作用，从而获得退热效果。结论：艾灸的效应是通过刺激穴位的多模式感受器实现的。
