Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 221 85 Lund, Sweden.
Chemosphere. 2012 Sep;88(11):1269-75. doi: 10.1016/j.chemosphere.2012.03.049. Epub 2012 Apr 10.
Perfluorinated compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are used in large quantities. They are persistent and found in measurable levels in human serum around the world. They have been associated with developmental, hepatic, and carcinogenic effects in animal studies. The aim of the present study was to describe levels of PFCs in serum among Inuits from Greenland and inhabitants from Warsaw, Poland and Kharkiv, Ukraine. Furthermore, the aim was to define social- and lifestyle related determinants of exposure for these compounds. Serum levels of seven PFCs were analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The concentrations of PFOS and PFOA were the highest of all PFCs in all three populations with a total amount of almost 90% of the PFCs. The mean levels of PFOS and PFOA were in the Greenlandic Inuits 52 and 4.8 ng mL(-1), in Poland 19 and 5.2 ng mL(-1), and in Ukraine 8.1 and 1.9 ng mL(-1), respectively. Thus, levels of PFCs in the serum of Inuits on Greenland were among the highest described in a general population whereas the levels in Poland were similar to other industrialized countries. The exposure in Ukraine was rather low. In the Greenlandic Inuit population, intake of seafood, tea, age and area of living were significant determinants of PFOS concentrations and explained about 22% of the variation. For the other populations no strong determinants were found.
全氟化合物（PFCs），如全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA），被大量使用。它们具有持久性，在世界各地的人类血清中都可以检测到可测量水平。它们在动物研究中与发育、肝脏和致癌作用有关。本研究的目的是描述格陵兰因纽特人和波兰华沙居民以及乌克兰哈尔科夫居民血清中 PFCs 的水平。此外，还旨在确定这些化合物暴露的社会和生活方式相关决定因素。通过液相色谱/串联质谱法（LC/MS/MS）分析了七种 PFCs 的血清水平。在所有三种人群中，PFOS 和 PFOA 的浓度是所有 PFCs 中最高的，占所有 PFCs 的近 90%。在格陵兰因纽特人中，PFOS 和 PFOA 的平均水平分别为 52 和 4.8ng/mL，在波兰为 19 和 5.2ng/mL，在乌克兰为 8.1 和 1.9ng/mL。因此，格陵兰因纽特人血清中 PFCs 的水平在一般人群中属于最高水平，而波兰的水平与其他工业化国家相似。乌克兰的暴露水平相当低。在格陵兰因纽特人群中，海鲜、茶、年龄和居住地区是 PFOS 浓度的重要决定因素，解释了约 22%的差异。对于其他人群，没有发现强烈的决定因素。
