Department of Neurosurgery, Oslo University Hospital, Norway.
Epilepsy Behav. 2012 May;24(1):44-8. doi: 10.1016/j.yebeh.2012.02.024. Epub 2012 Apr 10.
Electric Status Epilepticus during Sleep (ESES) occurs in children with and without epilepsy. It may be related to disturbances as autism spectrum disorder, attention-deficit hyperactivity disorder and acquired aphasia (Landau-Kleffner syndrome). Antiepileptic drug (AED) treatment has been reported in small studies without placebo control. This study was designed to assess AED effect in a placebo-controlled double-blind cross-over study. Levetiracetam (LEV) was chosen based on clinical evidence. Eighteen patients fulfilled the inclusion criteria. The mean spike index at baseline was 56, falling to a mean of 37 at the end of the LEV treatment period. Assessed with a 2-way ANOVA, there is a significant treatment effect (p<0.0002). To the best of our knowledge, this is the first placebo-controlled double-blind cross-over study for any AED in patients with ESES. The effect of LEV is comparable with its effect in treatment of epileptic seizures.
睡眠中癫痫电持续状态（ESES）可见于癫痫患儿和非癫痫患儿。它可能与自闭症谱系障碍、注意缺陷多动障碍和获得性失语（Landau-Kleffner 综合征）等障碍有关。在一些小型研究中报告了抗癫痫药物（AED）治疗，但没有安慰剂对照。本研究旨在评估 AED 治疗在安慰剂对照双盲交叉研究中的效果。选择左乙拉西坦（LEV）是基于临床证据。18 名患者符合纳入标准。基线时尖波指数的平均值为 56，在 LEV 治疗期末降至 37 的平均值。采用 2 因素方差分析，有显著的治疗效果（p<0.0002）。据我们所知，这是 ESES 患者中任何 AED 的首个安慰剂对照双盲交叉研究。LEV 的疗效可与治疗癫痫发作时的疗效相媲美。
