Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Clin Infect Dis. 2012 May;54(10):1427-36. doi: 10.1093/cid/cis211. Epub 2012 Apr 10.
Age-specific comparisons of influenza and respiratory syncytial virus (RSV) hospitalization rates can inform prevention efforts, including vaccine development plans. Previous US studies have not estimated jointly the burden of these viruses using similar data sources and over many seasons.
We estimated influenza and RSV hospitalizations in 5 age categories (<1, 1-4, 5-49, 50-64, and ≥65 years) with data for 13 states from 1993-1994 through 2007-2008. For each state and age group, we estimated the contribution of influenza and RSV to hospitalizations for respiratory and circulatory disease by using negative binomial regression models that incorporated weekly influenza and RSV surveillance data as covariates.
Mean rates of influenza and RSV hospitalizations were 63.5 (95% confidence interval [CI], 37.5-237) and 55.3 (95% CI, 44.4-107) per 100000 person-years, respectively. The highest hospitalization rates for influenza were among persons aged ≥65 years (309/100000; 95% CI, 186-1100) and those aged <1 year (151/100000; 95% CI, 151-660). For RSV, children aged <1 year had the highest hospitalization rate (2350/100000; 95% CI, 2220-2520) followed by those aged 1-4 years (178/100000; 95% CI, 155-230). Age-standardized annual rates per 100000 person-years varied substantially for influenza (33-100) but less for RSV (42-77).
Overall US hospitalization rates for influenza and RSV are similar; however, their age-specific burdens differ dramatically. Our estimates are consistent with those from previous studies focusing either on influenza or RSV. Our approach provides robust national comparisons of hospitalizations associated with these 2 viral respiratory pathogens by age group and over time.
对流感和呼吸道合胞病毒（RSV）住院率进行特定年龄组别的比较，可以为包括疫苗开发计划在内的预防工作提供信息。之前的美国研究没有使用类似的数据源和多个季节的数据来联合评估这两种病毒的负担。
我们使用 1993-1994 年至 2007-2008 年期间来自 13 个州的数据，对 5 个年龄组（<1、1-4、5-49、50-64 和≥65 岁）的流感和 RSV 住院率进行了估计。对于每个州和年龄组，我们使用负二项回归模型来估计流感和 RSV 对呼吸和循环系统疾病住院的贡献，模型中包含了每周的流感和 RSV 监测数据作为协变量。
流感和 RSV 的平均住院率分别为 63.5（95%置信区间[CI]，37.5-237）和 55.3（95%CI，44.4-107）/100000 人年。流感住院率最高的是≥65 岁的人群（309/100000；95%CI，186-1100）和<1 岁的人群（151/100000；95%CI，151-660）。对于 RSV，<1 岁的儿童住院率最高（2350/100000；95%CI，2220-2520），其次是 1-4 岁的儿童（178/100000；95%CI，155-230）。按年龄标准化的年住院率差异很大，流感为 33-100/100000 人年，而 RSV 为 42-77/100000 人年。
美国流感和 RSV 的总体住院率相似，但特定年龄组的负担差异很大。我们的估计与之前只关注流感或 RSV 的研究结果一致。我们的方法提供了按年龄组和时间对这两种病毒性呼吸道病原体相关住院的可靠的全国性比较。
