Haemato-oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research and Royal Marsden Hospital, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Nat Rev Cancer. 2012 Apr 12;12(5):335-48. doi: 10.1038/nrc3257.
Based on the clinical features of myeloma and related malignancies of plasma cells, it has been possible to generate a model system of myeloma progression from a normal plasma cell through smouldering myeloma to myeloma and then plasma cell leukaemia. Using this model system we can study at which points the genetic alterations identified through whole-tumour molecular analyses function in the initiation and progression of myeloma. Further genetic complexity, such as intraclonal heterogeneity, and insights into the molecular evolution and intraclonal dynamics in this model system are crucial to our understandings of tumour progression, treatment resistance and the use of currently available and future treatments.
根据骨髓瘤和浆细胞相关恶性肿瘤的临床特征，人们已经能够建立一个骨髓瘤进展的模型系统，从正常浆细胞经过冒烟型骨髓瘤发展为多发性骨髓瘤，然后是浆细胞白血病。利用这个模型系统，我们可以研究通过全肿瘤分子分析确定的遗传改变在多发性骨髓瘤的起始和进展中起作用的环节。进一步的遗传复杂性，如克隆内异质性，以及对该模型系统中分子进化和克隆内动态的深入了解，对于我们理解肿瘤进展、治疗耐药性以及当前和未来治疗方法的应用至关重要。
