Department of Biochemistry & Molecular Biology, Monash University, Clayton, Australia.
IUBMB Life. 2012 May;64(5):397-401. doi: 10.1002/iub.1021.
Bacterial infection has enormous global social and economic impacts stemming from effects on human health and agriculture. Although there are still many unanswered questions, decades of research has uncovered many of the pathogenic mechanisms at play. It is now clear that bacterial pathogens produce a plethora of proteins known as "toxins" and "effectors" that target a variety of physiological host processes during the course of infection. One of the targets of host targeted bacterial toxins and effectors are the mitochondria. The mitochondrial organelles are major players in many biological functions, including energy conversion to ATP and cell death pathways, which inherently makes them targets for bacterial proteins. We present a summary of the toxins targeted to mitochondria and for those that have been studied in finer detail, we also summarize what we know about the mechanisms of targeting and finally their action at the organelle.
细菌感染对人类健康和农业产生了巨大的全球社会和经济影响。尽管仍有许多未解决的问题，但数十年的研究已经揭示了许多致病机制。现在很清楚，细菌病原体产生了大量被称为“毒素”和“效应物”的蛋白质，这些蛋白质在感染过程中针对宿主的各种生理过程。宿主靶向细菌毒素和效应物的靶标之一是线粒体。线粒体细胞器是许多生物功能的主要参与者，包括能量转换为 ATP 和细胞死亡途径，这使得它们自然而然地成为细菌蛋白的靶标。我们总结了靶向线粒体的毒素，对于那些已经进行了更详细研究的毒素，我们还总结了我们对靶向机制及其在细胞器中的作用的了解。
