Kita Yuichiro, Miura Yutaka, Yagasaki Kazumi
Department of Applied Biological Chemistry, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
J Biomed Biotechnol. 2012;2012:672416. doi: 10.1155/2012/672416. Epub 2012 Feb 8.
Piceatannol is a stilbenoid, a metabolite of resveratrol found in red wine. Piceatannol and sera from rats orally given piceatannol were found to dose-dependently suppress both the proliferation and invasion of AH109A hepatoma cells in culture. Its antiproliferative effect was based on cell cycle arrest at lower concentration (25~50 μM) and on apoptosis induction at higher concentration (100 μM). Piceatannol suppressed reactive oxygen species-potentiated invasive capacity by scavenging the intracellular reactive oxygen species. These results suggest that piceatannol, unlike resveratrol, has a potential to suppress the hepatoma proliferation by inducing cell cycle arrest and apoptosis induction. They also suggest that the antioxidative property of piceatannol, like resveratrol, may be involved in its anti-invasive action. Subsequently, piceatannol was found to suppress the growth of solid tumor and metastasis in hepatoma-bearing rats. Thus, piceatannol may be a useful anticancer natural product.
白皮杉醇是一种芪类化合物，是红酒中白藜芦醇的代谢产物。研究发现，白皮杉醇以及经口服给予白皮杉醇的大鼠血清能够剂量依赖性地抑制培养的AH109A肝癌细胞的增殖和侵袭。其抗增殖作用在较低浓度（25~50μM）时基于细胞周期阻滞，在较高浓度（100μM）时基于诱导凋亡。白皮杉醇通过清除细胞内活性氧来抑制活性氧增强的侵袭能力。这些结果表明，与白藜芦醇不同，白皮杉醇具有通过诱导细胞周期阻滞和凋亡来抑制肝癌增殖的潜力。它们还表明，与白藜芦醇一样，白皮杉醇的抗氧化特性可能与其抗侵袭作用有关。随后，研究发现白皮杉醇可抑制荷肝癌大鼠实体瘤的生长和转移。因此，白皮杉醇可能是一种有用的抗癌天然产物。
