Michaeli Jennia, Weintraub Michael, Gross Eitan, Ginosar Yehuda, Ravitsky Vardit, Eizenman Einat, Mitrani Eduardo, Lebovich Meital, Laufer Neri, Kennedy Stephen, Revel Ariel
Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, 91120 Jerusalem, Israel.
Obstet Gynecol Int. 2012;2012:139193. doi: 10.1155/2012/139193. Epub 2012 Feb 16.
Children that undergo treatment for cancer are at risk of suffering from subfertility or hormonal dysfunction due to the detrimental effects of radiotherapy and chemotherapeutic agents on the gonads. Cryopreservation of ovarian tissue prior to treatment offers the possibility of restoring gonadal function after resumption of therapy. Effective counseling and management of pediatric patients is crucial for preserving their future reproductive potential. The purpose of this article is to review recent literature and to revise recommendations we made in a 2007 article. Pediatric hemato-oncology, reproductive endocrinology, surgery, anesthesia and bioethics perspectives are discussed and integrated to propose guidelines for offering ovarian cryopreservation to premenarcheal girls with cancer.
接受癌症治疗的儿童由于放疗和化疗药物对性腺的有害影响，有患生育力低下或激素功能障碍的风险。治疗前对卵巢组织进行冷冻保存为治疗恢复后恢复性腺功能提供了可能性。对儿科患者进行有效的咨询和管理对于保留他们未来的生殖潜力至关重要。本文的目的是回顾近期文献，并修订我们在2007年一篇文章中提出的建议。本文讨论并整合了儿科血液肿瘤学、生殖内分泌学、外科学、麻醉学和生物伦理学等方面的观点，以提出为患有癌症的青春期前女孩提供卵巢冷冻保存的指导原则。
