Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
PLoS One. 2012;7(4):e34866. doi: 10.1371/journal.pone.0034866. Epub 2012 Apr 4.
There is general consensus that season of birth influences the risk of developing psychiatric conditions later in life. We aimed to investigate whether the risk of schizophrenia (SC), bipolar affective disorder (BAD) and recurrent depressive disorder (RDD) is influenced by month of birth in England to a similar extent as other countries using the largest cohort of English patients collected to date (n = 57,971). When cases were compared to the general English population (n = 29,183,034) all diseases showed a seasonal distribution of births (SC p = 2.48E-05; BAD p = 0.019; RDD p = 0.015). This data has implications for future strategies of disease prevention.
人们普遍认为,出生季节会影响日后患上精神疾病的风险。我们旨在调查在英格兰,出生月份是否会像其他国家一样,对精神分裂症 (SC)、双相情感障碍 (BAD) 和复发性抑郁障碍 (RDD) 的发病风险产生类似的影响,为此我们使用了迄今为止收集到的最大的英格兰患者队列(n = 57971)进行研究。当将病例与一般的英格兰人群(n = 29183034)进行比较时,所有疾病的出生都呈现季节性分布(SC p = 2.48E-05;BAD p = 0.019;RDD p = 0.015)。该数据对未来的疾病预防策略具有重要意义。