Callahan Patrick, Liu Ping, Purcell Rosemary, Parker Alexandra G, Hetrick Sarah E
Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Locked Bag 10, Parkville, Victoria 3052, Australia.
Depress Res Treat. 2012;2012:820735. doi: 10.1155/2012/820735. Epub 2012 Mar 15.
Introduction. Depression in adolescents and young people is associated with reduced social, occupational, and interpersonal functioning, increases in suicide and self-harm behaviours, and problematic substance use. Age-appropriate, evidence-based treatments are required to provide optimal care. Methods. "Evidence mapping" methodology was used to quantify the nature and distribution of the extant high-quality research into the prevention and treatment of depression in young people across psychological, medical, and other treatment domains. Results. Prevention research is dominated by cognitive-behavioral- (CBT-) based interventions. Treatment studies predominantly consist of CBT and SSRI medication trials, with few trials of other psychological interventions or complementary/alternative treatments. Quality studies on relapse prevention and treatment for persistent depression are distinctly lacking. Conclusions. This map demonstrates opportunities for future research to address the numerous evidence gaps for interventions to prevent or treat depression in young people, which are of interest to clinical researchers, policy makers, and funding bodies.
引言。青少年抑郁症与社交、职业和人际功能下降、自杀和自我伤害行为增加以及物质使用问题有关。需要采用适合年龄且基于证据的治疗方法来提供最佳护理。方法。采用“证据图谱”方法来量化现有高质量研究在心理、医学和其他治疗领域对青少年抑郁症预防和治疗的性质及分布。结果。预防研究主要以认知行为疗法（CBT）为基础的干预措施为主。治疗研究主要包括CBT和选择性5-羟色胺再摄取抑制剂（SSRI）药物试验，其他心理干预或补充/替代治疗的试验很少。明显缺乏关于持续性抑郁症复发预防和治疗的高质量研究。结论。这一图谱展示了未来研究的机会，以填补青少年抑郁症预防或治疗干预措施方面众多的证据空白，这对临床研究人员、政策制定者和资助机构来说都很重要。
