Oliveira Paulo J, Carvalho Rui A, Portincasa Piero, Bonfrate Leonilde, Sardao Vilma A
CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.
J Lipids. 2012;2012:365798. doi: 10.1155/2012/365798. Epub 2012 Feb 1.
Menopause is a consequence of the normal aging process in women. This fact implies that the physiological and biochemical alterations resulting from menopause often blur with those from the aging process. It is thought that menopause in women presents a higher risk for cardiovascular disease although the precise mechanism is still under discussion. The postmenopause lipid profile is clearly altered, which can present a risk factor for cardiovascular disease. Due to the role of mitochondria in fatty acid oxidation, alterations of the lipid profile in the menopausal women will also influence mitochondrial fatty acid oxidation fluxes in several organs. In this paper, we propose that alterations of mitochondrial bioenergetics in the heart, consequence from normal aging and/or from the menopausal process, result in decreased fatty acid oxidation and accumulation of fatty acid intermediates in the cardiomyocyte cytosol, resulting in lipotoxicity and increasing the cardiovascular risk in the menopausal women.
更年期是女性正常衰老过程的结果。这一事实意味着，更年期导致的生理和生化改变常常与衰老过程中的改变相互混淆。尽管确切机制仍在讨论中，但人们认为女性更年期会增加患心血管疾病的风险。绝经后血脂谱明显改变，这可能是心血管疾病的一个危险因素。由于线粒体在脂肪酸氧化中起作用，更年期女性血脂谱的改变也会影响多个器官中线粒体脂肪酸氧化通量。在本文中，我们提出，心脏中线粒体生物能量学的改变，无论是正常衰老还是更年期过程导致的，都会导致脂肪酸氧化减少以及心肌细胞胞质中脂肪酸中间体的积累，从而导致脂毒性并增加更年期女性的心血管风险。
