Amin Shreyasee, Khosla Sundeep
Division of Rheumatology, Department of Internal Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
J Osteoporos. 2012;2012:129760. doi: 10.1155/2012/129760. Epub 2012 Feb 16.
The trabecular and cortical compartments of bone each contributes to bone strength. Until recently, assessment of trabecular and cortical microstructure has required a bone biopsy. Now, trabecular and cortical microstructure of peripheral bone sites can be determined noninvasively using high-resolution peripheral quantitative computed tomography (HR-pQCT). Studies that have used HR-pQCT to evaluate cohorts of both men and women have provided novel insights into the changes in bone microarchitecture that occur with age between the sexes, which may help to explain the lower fracture incidence in older men relative to women. This review will highlight observations from these studies on both the sex- and age-related differences in trabecular and cortical microstructure that may underlie the differences in bone strength, and thereby fracture risk, between men and women.
骨骼的小梁和皮质部分都对骨强度有贡献。直到最近，评估小梁和皮质微结构还需要进行骨活检。现在，使用高分辨率外周定量计算机断层扫描（HR-pQCT）可以无创地确定外周骨部位的小梁和皮质微结构。使用HR-pQCT评估男性和女性队列的研究，为两性随年龄增长而发生的骨微结构变化提供了新的见解，这可能有助于解释老年男性骨折发生率低于女性的原因。本综述将重点介绍这些研究中关于小梁和皮质微结构的性别和年龄差异的观察结果，这些差异可能是男女骨强度差异以及骨折风险差异的基础。
