铜催化的末端烯烃的氧化三氟甲基化反应：使用亲核 CF3SiMe3 的高效 C(sp3)-CF3 键形成。
Copper-catalyzed oxidative trifluoromethylation of terminal alkenes using nucleophilic CF3SiMe3: efficient C(sp3)-CF3 bond formation.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
出版信息
Org Lett. 2012 Apr 20;14(8):2106-9. doi: 10.1021/ol300639a. Epub 2012 Apr 12.
PMID:22497319
Abstract
An efficient C(sp(3))-CF(3) bond-forming reaction via Cu-catalyzed oxidative trifluoromethylation of terminal alkenes has been developed, which proceeds under mild conditions using readily available, less expensive CF(3)SiMe(3) as the source of the CF(3) group. This method allows access to a variety of trifluoromethylated allylic compounds.
摘要
一种高效的 C(sp(3))-CF(3) 键形成反应，通过铜催化的末端烯烃的氧化三氟甲基化反应实现，该反应在温和条件下进行，使用易得且较便宜的 CF(3)SiMe(3) 作为 CF(3) 基团的来源。该方法可用于多种三氟甲基化的烯丙基化合物。
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