铜催化的非活化烯烃的氧三氟甲基化反应。
Copper-catalyzed oxytrifluoromethylation of unactivated alkenes.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
出版信息
J Am Chem Soc. 2012 Aug 1;134(30):12462-5. doi: 10.1021/ja305840g. Epub 2012 Jul 23.
Abstract
A mild, versatile, and convenient method for the efficient oxytrifluoromethylation of unactivated alkenes based on a copper-catalyzed oxidative difunctionalization strategy has been developed. This methodology provides access to a variety of classes of synthetically useful CF(3)-containing building blocks from simple starting materials.
摘要
一种温和、通用且方便的方法，通过铜催化的氧化双官能化策略，实现了对非活化烯烃的高效氧三氟甲基化。该方法学为从简单起始原料合成各种具有合成用途的含 CF3 砌块提供了途径。
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