黏连蛋白在基因表达和 DNA 修复中的古老而演变的角色。
The ancient and evolving roles of cohesin in gene expression and DNA repair.
机构信息
Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
出版信息
Curr Biol. 2012 Apr 10;22(7):R240-50. doi: 10.1016/j.cub.2012.02.046.
Abstract
The cohesin complex, named for its key role in sister chromatid cohesion, also plays critical roles in gene regulation and DNA repair. It performs all three functions in single cell eukaryotes such as yeasts, and in higher organisms such as man. Minor disruption of cohesin function has significant consequences for human development, even in the absence of measurable effects on chromatid cohesion or chromosome segregation. Here we survey the roles of cohesin in gene regulation and DNA repair, and how these functions vary from yeast to man.
摘要
黏合蛋白复合体因其在姐妹染色单体黏合中的关键作用而得名，在基因调控和 DNA 修复中也发挥着关键作用。它在单细胞真核生物（如酵母）和高等生物（如人类）中执行这三种功能。黏合蛋白功能的轻微破坏对人类发育有重大影响，即使对染色单体黏合或染色体分离没有可测量的影响也是如此。在这里，我们调查黏合蛋白在基因调控和 DNA 修复中的作用，以及这些功能如何从酵母到人发生变化。
相似文献
1
The ancient and evolving roles of cohesin in gene expression and DNA repair.黏连蛋白在基因表达和 DNA 修复中的古老而演变的角色。
Curr Biol. 2012 Apr 10;22(7):R240-50. doi: 10.1016/j.cub.2012.02.046.
2
[Sister chromatid cohesion complex in Eukaryota].真核生物中的姐妹染色单体黏连复合体
Postepy Biochem. 2010;56(1):41-54.
3
Cohesin at active genes: a unifying theme for cohesin and gene expression from model organisms to humans.黏连蛋白在活性基因处：从模式生物到人，黏连蛋白和基因表达的统一主题。
Curr Opin Cell Biol. 2013 Jun;25(3):327-33. doi: 10.1016/j.ceb.2013.02.003. Epub 2013 Mar 1.
4
Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells.果蝇Nipped-B与黏连蛋白在体细胞和减数分裂细胞中的功能联系。
Chromosoma. 2008 Feb;117(1):51-66. doi: 10.1007/s00412-007-0125-5. Epub 2007 Oct 2.
5
The cohesin complex and its roles in chromosome biology.黏连蛋白复合体及其在染色体生物学中的作用。
Genes Dev. 2008 Nov 15;22(22):3089-114. doi: 10.1101/gad.1724308.
6
Chromosome cohesion - rings, knots, orcs and fellowship.染色体黏连——环、结、纺锤体组装因子与伙伴关系。
J Cell Sci. 2008 Jul 1;121(Pt 13):2107-14. doi: 10.1242/jcs.029132.
7
The Many Roles of Cohesin in Drosophila Gene Transcription.黏连蛋白在果蝇基因转录中的多种作用。
Trends Genet. 2019 Jul;35(7):542-551. doi: 10.1016/j.tig.2019.04.002. Epub 2019 May 23.
8
Cohesin plays a dual role in gene regulation and sister-chromatid cohesion during meiosis in Saccharomyces cerevisiae.黏合蛋白在酿酒酵母减数分裂过程中基因调控和姐妹染色单体黏合中起双重作用。
Genetics. 2011 Apr;187(4):1041-51. doi: 10.1534/genetics.110.122358. Epub 2011 Jan 26.
9
Handcuff for sisters: a new model for sister chromatid cohesion.姐妹染色单体黏连的手铐：一种姐妹染色单体黏连的新模式。
Cell Cycle. 2009 Feb 1;8(3):399-402. doi: 10.4161/cc.8.3.7586. Epub 2009 Feb 10.
10
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.Brca2、Pds5 和 Wapl 差异调控着黏连蛋白在染色体上的关联和功能。
PLoS Genet. 2018 Feb 15;14(2):e1007225. doi: 10.1371/journal.pgen.1007225. eCollection 2018 Feb.
引用本文的文献
1
Discovering new hub genes of dilated cardiomyopathy.发现扩张型心肌病的新枢纽基因。
ESC Heart Fail. 2025 Mar 12. doi: 10.1002/ehf2.15259.
2
Cohesin composition and dosage independently affect early development in zebrafish.黏连蛋白的组成和剂量独立影响斑马鱼的早期发育。
Development. 2024 Aug 1;151(15). doi: 10.1242/dev.202593.
3
Recent Advances in Molecular and Genetic Research on Uveal Melanoma.葡萄膜黑色素瘤的分子遗传学研究进展
Cells. 2024 Jun 12;13(12):1023. doi: 10.3390/cells13121023.
4
PRAME induces genomic instability in uveal melanoma.PRAME 导致葡萄膜黑色素瘤的基因组不稳定。
Oncogene. 2024 Feb;43(8):555-565. doi: 10.1038/s41388-023-02887-0. Epub 2023 Nov 29.
5
Chromatin assembly factor-1 preserves genome stability in Δ cells by promoting sister chromatid cohesion.染色质组装因子-1通过促进姐妹染色单体黏连来维持Δ细胞中的基因组稳定性。
Cell Stress. 2023 Aug 14;7(9):69-89. doi: 10.15698/cst2023.09.289. eCollection 2023 Sep 11.
6
Cohesin contributes to transcriptional repression of stage-specific genes in the human malaria parasite.黏连蛋白有助于人类疟原虫中阶段特异性基因的转录抑制。
EMBO Rep. 2023 Oct 9;24(10):e57090. doi: 10.15252/embr.202357090. Epub 2023 Aug 18.
7
Proliferating cell nuclear antigen inhibitors block distinct stages of herpes simplex virus infection.增殖细胞核抗原抑制剂阻断单纯疱疹病毒感染的不同阶段。
PLoS Pathog. 2023 Jul 24;19(7):e1011539. doi: 10.1371/journal.ppat.1011539. eCollection 2023 Jul.
8
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures.单分子成像技术研究基因组维持蛋白与特定 DNA 序列和结构的相互作用。
DNA Repair (Amst). 2023 Aug;128:103528. doi: 10.1016/j.dnarep.2023.103528. Epub 2023 Jun 24.
9
A Novel de Novo Variant in 5' UTR of the Associated with Cornelia de Lange Syndrome.一个与 Cornelia de Lange 综合征相关的 5'UTR 上的新型从头变异。
Genes (Basel). 2022 Apr 22;13(5):740. doi: 10.3390/genes13050740.
10
The Interplay of Cohesin and RNA Processing Factors: The Impact of Their Alterations on Genome Stability.黏连蛋白与 RNA 加工因子的相互作用：其改变对基因组稳定性的影响。
Int J Mol Sci. 2022 Apr 1;23(7):3939. doi: 10.3390/ijms23073939.
本文引用的文献
1
SMC1A codon 496 mutations affect the cellular response to genotoxic treatments.SMC1A 密码子 496 突变影响细胞对遗传毒性处理的反应。
Am J Med Genet A. 2012 Jan;158A(1):224-8. doi: 10.1002/ajmg.a.34384. Epub 2011 Dec 2.
2
Causes of death and autopsy findings in a large study cohort of individuals with Cornelia de Lange syndrome and review of the literature.Cornelia de Lange 综合征大样本队列研究的死因和尸检结果，并文献复习。
Am J Med Genet A. 2011 Dec;155A(12):3007-24. doi: 10.1002/ajmg.a.34329. Epub 2011 Nov 8.
3
Cohesin: a catenase with separate entry and exit gates?黏连蛋白：具有独立进入和退出通道的连接酶？
Nat Cell Biol. 2011 Oct 3;13(10):1170-7. doi: 10.1038/ncb2349.
4
Cohesin selectively binds and regulates genes with paused RNA polymerase.黏合蛋白选择性地结合和调节 RNA 聚合酶暂停的基因。
Curr Biol. 2011 Oct 11;21(19):1624-34. doi: 10.1016/j.cub.2011.08.036. Epub 2011 Sep 29.
5
Sticking a fork in cohesin--it's not done yet!用叉子戳开黏连蛋白——还没完成呢！
Trends Genet. 2011 Dec;27(12):499-506. doi: 10.1016/j.tig.2011.08.004. Epub 2011 Sep 22.
6
Gene regulation by cohesin in cancer: is the ring an unexpected party to proliferation?黏连蛋白在癌症中的基因调控：环是否是增殖的意外参与者？
Mol Cancer Res. 2011 Dec;9(12):1587-607. doi: 10.1158/1541-7786.MCR-11-0382. Epub 2011 Sep 22.
7
Cohesin regulates MHC class II genes through interactions with MHC class II insulators.黏合蛋白通过与 MHC Ⅱ类基因隔离子相互作用调节 MHC Ⅱ类基因。
J Immunol. 2011 Oct 15;187(8):4236-44. doi: 10.4049/jimmunol.1100688. Epub 2011 Sep 12.
8
Mechanism of glycyrrhizic acid inhibition of Kaposi's sarcoma-associated herpesvirus: disruption of CTCF-cohesin-mediated RNA polymerase II pausing and sister chromatid cohesion.甘草酸抑制卡波西肉瘤相关疱疹病毒的机制：破坏 CTCF-黏合蛋白介导的 RNA 聚合酶 II 暂停和姐妹染色单体黏合。
J Virol. 2011 Nov;85(21):11159-69. doi: 10.1128/JVI.00720-11. Epub 2011 Aug 31.
9
Coordination of KSHV latent and lytic gene control by CTCF-cohesin mediated chromosome conformation.CTCF-cohesin 介导的染色体构象调控 KSHV 潜伏和裂解基因的协调。
PLoS Pathog. 2011 Aug;7(8):e1002140. doi: 10.1371/journal.ppat.1002140. Epub 2011 Aug 18.
10
Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint.SCC-2 加载减数分裂黏连蛋白对于 DSB 的早期处理和 DNA 损伤检查点是必需的。
Curr Biol. 2011 Sep 13;21(17):1421-30. doi: 10.1016/j.cub.2011.07.007.
Zotero 插件