Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
Curr Biol. 2012 Apr 10;22(7):R240-50. doi: 10.1016/j.cub.2012.02.046.
The cohesin complex, named for its key role in sister chromatid cohesion, also plays critical roles in gene regulation and DNA repair. It performs all three functions in single cell eukaryotes such as yeasts, and in higher organisms such as man. Minor disruption of cohesin function has significant consequences for human development, even in the absence of measurable effects on chromatid cohesion or chromosome segregation. Here we survey the roles of cohesin in gene regulation and DNA repair, and how these functions vary from yeast to man.
黏合蛋白复合体因其在姐妹染色单体黏合中的关键作用而得名，在基因调控和 DNA 修复中也发挥着关键作用。它在单细胞真核生物（如酵母）和高等生物（如人类）中执行这三种功能。黏合蛋白功能的轻微破坏对人类发育有重大影响，即使对染色单体黏合或染色体分离没有可测量的影响也是如此。在这里，我们调查黏合蛋白在基因调控和 DNA 修复中的作用，以及这些功能如何从酵母到人发生变化。
