Lund E
Institute of Community Medicine, University of Tromsø, Norway.
Int J Cancer. 1990 Dec 15;46(6):998-1000. doi: 10.1002/ijc.2910460608.
The association between number of children of current marriage reported by 431,604 women aged 45-74 years at the Norwegian Census in 1970 and mortality, at follow-up through 1985, from hormone-dependent cancers, i.e., cancers of breast, corpus uteri and ovary combined, has been investigated. The reduction in age-adjusted mortality was 9.6% (95% confidence interval; 8.3-10.9%) for each child with no deviation from linearity. Women with 8-11 children had a relative risk of 0.34 (0.25-0.47) compared to nullipara. Adjustment for age at first birth slightly changed the effect of number of children on mortality to 9.3% per child. The reduction in mortality per child was for cancer of the breast 7.2%, corpus uteri 12.2% and ovary 12.7%. Our findings indicate that having few children is a major risk factor for death from the 3 hormone-dependent cancers combined.
对1970年挪威人口普查中431,604名45至74岁女性报告的当前婚姻子女数与截至1985年随访期间激素依赖性癌症（即乳腺癌、子宫体癌和卵巢癌合并）死亡率之间的关联进行了调查。每个子女的年龄调整死亡率降低了9.6%（95%置信区间：8.3 - 10.9%），且无偏离线性关系。与未生育女性相比，生育8 - 11个子女的女性相对风险为0.34（0.25 - 0.47）。对初产年龄进行调整后，子女数对死亡率的影响略有变化，每个子女为9.3%。每个子女的死亡率降低幅度为：乳腺癌7.2%，子宫体癌12.2%，卵巢癌12.7%。我们的研究结果表明，子女少是这三种激素依赖性癌症合并导致死亡的主要危险因素。
