Løchen M L, Lund E
Institute of Community Medicine, University of Tromsø, Norway.
Acta Obstet Gynecol Scand. 1997 Apr;76(4):373-7. doi: 10.1111/j.1600-0412.1997.tb07996.x.
To investigate the mortality from cancer of the corpus uteri in relation to parity and age at first and last birth.
A cohort of 431,604 married women aged 45-74 years at the Norwegian Census in 1970 was followed over 15 years. A total of 752 deaths from cancer of the corpus uteri were diagnosed during follow-up.
All age groups showed significant trends of decreasing mortality rates with increasing number of children. The age-adjusted reduction in mortality was 9.2% (95% CI 5.2-13.0) for each child. Women with 8-11 children had a relative risk of 0.35 (95% CI 0.14-0.85) compared to nulliparous women. For first birth at age > = 35 years versus < = 19 years, the relative risk was 0.53 (95% CI 0.34-0.83). No significant effect of age at last birth was found.
This study supports the notion that high parity and postponing the first delivery may reduce the risk of uterine cancer death.
研究子宫体癌死亡率与产次以及首次生育和末次生育年龄之间的关系。
对1970年挪威人口普查时年龄在45 - 74岁的431,604名已婚女性进行了为期15年的随访。随访期间共诊断出752例子宫体癌死亡病例。
所有年龄组均显示随着子女数量增加，死亡率呈显著下降趋势。每增加一个孩子，年龄调整后的死亡率降低9.2%（95%可信区间5.2 - 13.0）。与未生育女性相比，生育8 - 11个孩子的女性相对风险为0.35（95%可信区间0.14 - 0.85）。首次生育年龄≥35岁与≤19岁相比，相对风险为0.53（95%可信区间0.34 - 0.83）。未发现末次生育年龄有显著影响。
本研究支持高生育次数和推迟首次分娩可能降低子宫癌死亡风险这一观点。
