Department of Neonatology, Trinity Mother Frances Health System, Tyler, TX 75703, USA.
J Perinatol. 2013 Feb;33(2):126-33. doi: 10.1038/jp.2012.39. Epub 2012 Apr 12.
Evaluate the efficacy of phototherapy (PT) devices and the outcomes of extremely premature infants treated with those devices.
This substudy of the National Institute of Child Health and Human Development Neonatal Research Network PT trial included 1404 infants treated with a single type of PT device during the first 24±12 h of treatment. The absolute (primary outcome) and relative decrease in total serum bilirubin (TSB) and other measures were evaluated. For infants treated with one PT type during the 2-week intervention period (n=1223), adjusted outcomes at discharge and 18 to 22 months corrected age were determined.
In the first 24 h, the adjusted absolute (mean (±s.d.)) and relative (%) decrease in TSB (mg dl(-1)) were: light-emitting diodes (LEDs) -2.2 (±3), -22%; Spotlights -1.7 (±2), -19%; Banks -1.3 (±3), -8%; Blankets -0.8 (±3), -1%; (P<0.0002). Some findings at 18 to 22 months differed between groups.
LEDs achieved the greatest initial absolute reduction in TSB but were similar to Spots in the other performance measures. Long-term effects of PT devices in extremely premature infants deserve rigorous evaluation.
评估光疗（PT）设备的疗效以及使用这些设备治疗极早产儿的结果。
本研究是国立儿童健康与人类发展研究所新生儿研究网络 PT 试验的子研究，纳入了 1404 名在治疗的头 24±12 小时内接受单一类型 PT 设备治疗的婴儿。评估了总血清胆红素（TSB）的绝对（主要结局）和相对下降以及其他指标。对于在 2 周干预期间接受一种 PT 类型治疗的婴儿（n=1223），确定了出院时和校正 18 至 22 个月龄时的调整结局。
在最初的 24 小时内，调整后的 TSB（mg/dl(-1)）绝对（均值（±s.d.））和相对（%）下降值分别为：发光二极管（LEDs）-2.2（±3），-22%；聚光灯-1.7（±2），-19%；托架-1.3（±3），-8%；毯子-0.8（±3），-1%；（P<0.0002）。18 至 22 个月时的一些发现在组间存在差异。
LEDs 在初始 TSB 绝对下降方面取得了最大的效果，但在其他性能指标上与 Spots 相似。极早产儿使用 PT 设备的长期效果值得严格评估。
