Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
Dalton Trans. 2012 May 28;41(20):6189-94. doi: 10.1039/c2dt30192j. Epub 2012 Apr 13.
A new two-photon fluorescent Cd(2+) probe APQ is developed by introducing a N(1),N(1)-dimethyl-N(2)-(pyridin-2-ylmethyl)ethane-1,2-diamine binding group and a 4-methoxyphenylvinyl conjugation-enhancing group to the 2- and 6-positions of quinoline. This probe shows a large red shift and good emission enhancement under Cd(2+) binding. It also exhibits a high ion selectivity for Cd(2+) (especially over Zn(2+)) and a large two-photon absorption cross section at 710 nm. Two-photon microscopy imaging studies reveal that the new probe is non-toxic and cell-permeable and can be used to detect intracellular Cd(2+) under two-photon excitation.
一种新的双光子荧光 Cd(2+)探针 APQ 通过在喹啉的 2-和 6-位引入 N(1)、N(1)-二甲基-N(2)-(吡啶-2-基甲基)乙二胺结合基团和 4-甲氧基苯乙烯共轭增强基团来开发。该探针在与 Cd(2+)结合时表现出较大的红移和良好的发射增强。它还表现出对 Cd(2+)（尤其是 Zn(2+)）的高离子选择性和在 710nm 处的大双光子吸收截面。双光子显微镜成像研究表明，新探针具有非毒性和细胞通透性，可用于在双光子激发下检测细胞内 Cd(2+)。
