Kerr Kathleen F
University of Washington, USA.
Stat Appl Genet Mol Biol. 2012 Jan 13;11(1):Article 10. doi: 10.1515/1544-6115.1583.
We discuss the definition and application of design criteria for evaluating the efficiency of 2-color microarray designs. First, we point out that design optimality criteria are defined differently for the regression and block design settings. This has caused some confusion in the literature and warrants clarification. Linear models for microarray data analysis have equivalent formulations as ANOVA or regression models. However, this equivalence does not extend to design criteria. We discuss optimality criterion, and argue against applying regression-style D-optimality to the microarray design problem. We further disfavor E- and D-optimality (as defined in block design) because they are not attuned to scientific questions of interest.
我们讨论了用于评估双色微阵列设计效率的设计标准的定义和应用。首先，我们指出，设计最优性标准在回归设计和区组设计设置中的定义不同。这在文献中造成了一些混淆，需要加以澄清。用于微阵列数据分析的线性模型与方差分析或回归模型具有等效的形式。然而，这种等效性并不适用于设计标准。我们讨论了最优性标准，并反对将回归风格的D最优性应用于微阵列设计问题。我们进一步不赞成E最优性和D最优性（如在区组设计中所定义的），因为它们与感兴趣的科学问题不相适应。
