Shanmugaratnam K, Chan S H, de-Thé G, Goh J E, Khor T H, Simons M J, Tye C Y
Cancer. 1979 Sep;44(3):1029-44. doi: 10.1002/1097-0142(197909)44:3<1029::aid-cncr2820440335>3.0.co;2-5.
A total of 363 cases of nasopharyngeal carcinoma (NPC) in Singapore were classified into squamous cell carcinoma (SCC; 73 cases), non-keratinizing carcinoma (NKC; 178 cases) and undifferentiated carcinoma (UC; 172 cases). Possible biological differences between these histologic types and between tumors with and without lymphocytic infiltration were investigated by correlations with survival rates and with selected epidemiologic, immunovirologic, and immunogenetic data on the disease. The 5-year survival rates following radiotherapy were 25.3% for all cases and 58.8% for tumors restricted to the nasopharynx. The 5-year survival rate for SCC was poorer than for the combined NKC and UC groups (p less than 0.05). The 3-year survival rate was better for tumors with lymphocytic infiltration (p less than 0.05), but there were no differences in the 5-year survivals. The survival rates were better in females (p less than 0.01) and in the younger age groups (p less than 0.01). There were no significant correlations between histopathology of NPC and the distributions of cases by age, sex, HLA antigen profiles, or cell-mediated immune status. Squamous cell carcinoma was associated with lower levels of antibodies to the Epstein-Barr nuclear antigen (p less than 0.05), but there were no differences with respect to antibodies against other EBV related antigens. These findings support the view that SCC, NKC, and UC of the nasopharynx, as defined in the WHO classification, are variants of a fairly homogeneous group of neoplasms in the Singapore population.
新加坡共有363例鼻咽癌患者，被分为鳞状细胞癌（SCC；73例）、非角化癌（NKC；178例）和未分化癌（UC；172例）。通过与生存率以及该疾病的特定流行病学、免疫病毒学和免疫遗传学数据进行相关性分析，研究了这些组织学类型之间以及有和没有淋巴细胞浸润的肿瘤之间可能存在的生物学差异。放疗后的5年生存率，所有病例为25.3%，局限于鼻咽部的肿瘤为58.8%。SCC的5年生存率低于NKC和UC合并组（p小于0.05）。有淋巴细胞浸润的肿瘤3年生存率更高（p小于0.05），但5年生存率无差异。女性（p小于0.01）和较年轻年龄组（p小于0.01）的生存率更高。鼻咽癌的组织病理学与病例按年龄、性别、HLA抗原谱或细胞介导免疫状态的分布之间无显著相关性。鳞状细胞癌与抗EB病毒核抗原抗体水平较低相关（p小于0.05），但在针对其他EBV相关抗原的抗体方面无差异。这些发现支持以下观点：WHO分类中定义的鼻咽部SCC、NKC和UC是新加坡人群中一组相当同质的肿瘤变体。
