Schnoke Allison T, Brooks Dennis E, Wilkie David A, Dwyer Ann E, Matthews Andrew G, Gilger Brian C, Hendrix Diane V H, Pickett Phillip, Grauwels Magda, Monroe Christine, Plummer Caryn E
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
Vet Ophthalmol. 2013 Jan;16(1):35-42. doi: 10.1111/j.1463-5224.2012.01016.x. Epub 2012 Apr 13.
To describe the clinical findings and prognosis for extraocular lymphoma in the horse.
Retrospective medical records study of horses diagnosed with third eyelid, corneoscleral, conjunctival, and/or eyelid lymphoma from multiple academic and private veterinary institutions. Data collected from the medical records included signalment, clinical descriptions of the extraocular lesions, treatment, and treatment outcomes. Nonparametric statistical analysis was performed with Fischer's exact tests.
Extraocular lymphoma involving the eyelid, third eyelid, cornea, sclera, and/or conjunctiva was diagnosed in 26 horses. Differences in signalment, unilateral vs. bilateral extraocular involvement, and single vs. multiple extraocular lesion locations held no significance in terms of outcome.
Horses with lesions localized to the eyelid or other nonextraocular cutaneous locations had a significantly higher chance of negative outcome when compared to the horses with no eyelid or cutaneous involvement (P = 0.019). Lesions to the third eyelid, corneosclera, and conjunctiva were either nodular or diffuse in nature. Nodular lesions when compared to diffuse lesions were associated with a higher chance of a positive outcome (P = 0.007). Surgical resection of the extraocular lesions as part of the treatment produced a statistically higher chance of a positive outcome when compared to horses where resection was not performed (P = 0.03).
The prognosis for clinical remission in horses with extraocular lymphoma is generally fair to good, as long as the affected tissues are completely excised, and there is no eyelid or cutaneous involvement. Horses diagnosed with the nodular form of extraocular lymphoma seem to have the best prognosis with complete excision.
描述马眼外淋巴瘤的临床症状及预后。
对多家学术及私人兽医机构诊断为第三眼睑、角膜巩膜、结膜和/或眼睑淋巴瘤的马匹进行回顾性病历研究。从病历中收集的数据包括特征、眼外病变的临床描述、治疗方法及治疗结果。采用费舍尔精确检验进行非参数统计分析。
26匹马被诊断为累及眼睑、第三眼睑、角膜、巩膜和/或结膜的眼外淋巴瘤。在预后方面，特征、单侧与双侧眼外受累以及单个与多个眼外病变部位的差异无统计学意义。
与未累及眼睑或皮肤的马匹相比，病变局限于眼睑或其他非眼外皮肤部位的马匹出现不良预后的可能性显著更高（P = 0.019）。第三眼睑、角膜巩膜和结膜的病变本质上为结节状或弥漫性。与弥漫性病变相比，结节状病变出现良好预后的可能性更高（P = 0.007）。与未进行切除术的马匹相比，作为治疗一部分的眼外病变手术切除产生良好预后的统计学可能性更高（P = 0.03）。
只要受影响组织被完全切除且未累及眼睑或皮肤，马眼外淋巴瘤临床缓解的预后通常为中等至良好。诊断为结节型眼外淋巴瘤的马匹在完全切除后似乎预后最佳。
