劫持亮氨酰-tRNA 合成酶进行氨基酸依赖的 TORC1 调控。
Hijacking leucyl-tRNA synthetase for amino acid-dependent regulation of TORC1.
机构信息
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
出版信息
Mol Cell. 2012 Apr 13;46(1):4-6. doi: 10.1016/j.molcel.2012.03.028.
Abstract
TORC1 activity in all eukaryotes is dependent on amino acid availability. However, the mechanism through which TORC1 senses amino acids is still a mystery. In the current issues of Molecular Cell and Cell, Bonfils et al. (2012) and Han et al. (2012) implicate leucyl-tRNA synthetase in this evolving story.
摘要
所有真核生物中 TORC1 的活性都依赖于氨基酸的可获得性。然而，TORC1 感知氨基酸的机制仍然是一个谜。在本期的《分子细胞》和《细胞》杂志上，Bonfils 等人（2012）和 Han 等人（2012）将亮氨酰-tRNA 合成酶牵涉到这个不断发展的故事中。
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