Hebda P A, Klingbeil C K, Abraham J A, Fiddes J C
Department of Dermatology, University of Pittsburgh, School of Medicine, PA 15261.
J Invest Dermatol. 1990 Dec;95(6):626-31. doi: 10.1111/1523-1747.ep12513528.
Basic fibroblast growth factor (bFGF) has recently been shown to be a mitogen for keratinocytes. This observation has now been extended in a porcine model of epidermal wound healing. A single application of recombinant human bFGF given at the time of injury to healthy animals accelerated the rate of epithelialization by 20%; multiple applications gave no greater effect than the single application. Histologic analysis of biopsies of these partial-thickness wounds taken during bFGF-mediated healing supported the assessment of an enhanced rate of epithelialization and an earlier onset of dermal healing. Because no histologic abnormalities were observed, bFGF induced an acceleration of what appears to be the normal healing process.
碱性成纤维细胞生长因子（bFGF）最近已被证明是角质形成细胞的促有丝分裂原。这一观察结果现已在猪表皮伤口愈合模型中得到扩展。在健康动物受伤时单次应用重组人bFGF可使上皮化速率加快20%；多次应用的效果并不比单次应用更好。在bFGF介导的愈合过程中对这些部分厚度伤口的活检组织进行组织学分析，支持了上皮化速率加快和真皮愈合提前开始的评估。由于未观察到组织学异常，bFGF似乎加速了正常的愈合过程。
