Lamey P J, Savage A P, Fisher B M, Bloom S R, Frier B M
Department of Oral Medicine, Glasgow Dental Hospital and School, Scotland.
J Oral Pathol Med. 1990 Sep;19(8):351-4. doi: 10.1111/j.1600-0714.1990.tb00858.x.
Parotid saliva was collected over a 12-min period from 24 insulin dependent diabetic patients with varying degrees of autonomic neuropathy and 12 age and sex matched non-diabetic controls. Epidermal growth factor (EGF) concentrations in saliva were measured by radio-immunoassay. The EGF concentrations in diabetics with no autonomic neuropathy or with combined autonomic neuropathy were equivalent but secretion of EGF was significantly elevated at the 6- and 12-min periods of collection in diabetic patients with early or established autonomic neuropathy. It is postulated that when parasympathetic autonomic neuropathy is present a relative "over-activity" of the sympathetic innervation promotes release of salivary EGF. This sympathetic predominance may maintain salivary EGF concentration despite the elevated salivary flow and volume which is associated with parasympathetic autonomic neuropathy.
在12分钟内，从24名患有不同程度自主神经病变的胰岛素依赖型糖尿病患者以及12名年龄和性别匹配的非糖尿病对照者中收集腮腺唾液。通过放射免疫测定法测量唾液中表皮生长因子（EGF）的浓度。无自主神经病变或合并自主神经病变的糖尿病患者的EGF浓度相当，但在患有早期或已确诊自主神经病变的糖尿病患者中，在收集的第6分钟和第12分钟时，EGF的分泌显著升高。据推测，当存在副交感神经自主神经病变时，交感神经支配的相对“过度活跃”会促进唾液EGF的释放。尽管副交感神经自主神经病变会导致唾液流量和体积增加，但这种交感神经优势可能会维持唾液EGF浓度。
