Lamey P J, Fisher B M, Frier B M
Diabet Med. 1986 Nov-Dec;3(6):537-40. doi: 10.1111/j.1464-5491.1986.tb00810.x.
Stimulated parotid salivary flow studies were performed on 20 non-diabetic subjects and on 30 patients with insulin-dependent diabetes mellitus who had been screened for autonomic neuropathy using tests of cardiovascular reflexes. Electrical gustometry was performed to detect the taste threshold. The stimulated parotid salivary flow rates of diabetics with no autonomic neuropathy or early parasympathetic autonomic dysfunction alone were similar to those of non-diabetic subjects. Diabetic patients with established parasympathetic autonomic neuropathy had significantly higher salivary flow rates as did those with combined sympathetic and parasympathetic neuropathies. Taste thresholds did not correlate either with the duration of the diabetes or with the presence of autonomic neuropathy. The cause of the increased salivary flow associated with diabetic autonomic neuropathy is unclear. It may represent the removal of a neural inhibitory mechanism which modulates salivary flow, or the effects of long-standing diabetes on salivary secretion.
对20名非糖尿病受试者以及30名使用心血管反射测试筛查过自主神经病变的胰岛素依赖型糖尿病患者进行了刺激性腮腺唾液流量研究。采用电味觉测量法检测味觉阈值。无自主神经病变或仅存在早期副交感神经自主神经功能障碍的糖尿病患者的刺激性腮腺唾液流速与非糖尿病受试者相似。已确诊副交感神经自主神经病变的糖尿病患者以及同时存在交感神经和副交感神经病变的患者的唾液流速显著更高。味觉阈值与糖尿病病程或自主神经病变的存在均无相关性。与糖尿病自主神经病变相关的唾液流量增加的原因尚不清楚。这可能代表着调节唾液流量的神经抑制机制被消除，或者是长期糖尿病对唾液分泌的影响。
