University of Pennsylvania, Department of Physics and Astronomy, 3231 Walnut Street, Philadelphia, Pennsylvania 19104, USA.
J Biomed Opt. 2012 Mar;17(3):037007. doi: 10.1117/1.JBO.17.3.037007.
Diffuse correlation spectroscopy (DCS) is a novel optical technique that appears to be an excellent tool for assessing cerebral blood flow in a continuous and non-invasive manner at the bedside. We present new clinical validation of the DCS methodology by demonstrating strong agreement between DCS indices of relative cerebral blood flow and indices based on phase-encoded velocity mapping magnetic resonance imaging (VENC MRI) of relative blood flow in the jugular veins and superior vena cava. Data were acquired from 46 children with single ventricle cardiac lesions during a hypercapnia intervention. Significant increases in cerebral blood flow, measured both by DCS and by VENC MRI, as well as significant increases in oxyhemoglobin concentration, and total hemoglobin concentration, were observed during hypercapnia. Comparison of blood flow changes measured by VENC MRI in the jugular veins and by DCS revealed a strong linear relationship, R=0.88, p<0.001, slope=0.91±0.07. Similar correlations were observed between DCS and VENC MRI in the superior vena cava, R=0.77, slope=0.99±0.12, p<0.001. The relationship between VENC MRI in the aorta and DCS, a negative control, was weakly correlated, R=0.46, slope=1.77±0.45, p<0.001.
漫射相关光谱学（DCS）是一种新颖的光学技术，似乎是一种在床边以连续和非侵入方式评估脑血流的极佳工具。我们通过证明 DCS 相对脑血流指数与颈静脉和上腔静脉相对血流的相位编码速度映射磁共振成像（VENC MRI）指数之间具有很强的一致性，对 DCS 方法进行了新的临床验证。来自 46 名患有单心室心脏病变的儿童的数据在高碳酸血症干预期间获得。在高碳酸血症期间，通过 DCS 和 VENC MRI 测量的脑血流均显著增加，氧合血红蛋白浓度和总血红蛋白浓度也显著增加。在颈静脉中通过 VENC MRI 测量的血流量变化与 DCS 的比较显示出很强的线性关系，R=0.88，p<0.001，斜率=0.91±0.07。在上腔静脉中也观察到 DCS 和 VENC MRI 之间的类似相关性，R=0.77，斜率=0.99±0.12，p<0.001。主动脉 VENC MRI 与 DCS（阴性对照）之间的关系相关性较弱，R=0.46，斜率=1.77±0.45，p<0.001。
