Department of Neurology, Justus-Liebig University, Giessen, Germany.
Ultrasound Med Biol. 2012 Jun;38(6):989-96. doi: 10.1016/j.ultrasmedbio.2012.02.027. Epub 2012 Apr 12.
The neurovascular coupling describes a vasoregulative principle of the brain that adapts local cerebral blood flow in accordance with the underlying neuronal activity. It is the basis of modern indirect brain imaging techniques. Because of its wide availability and high tolerability the functional transcranial Doppler has been often used to assess brain function in clinical conditions. In the present paper we will give an overview of the current understanding of the coupling, explain basic principles of the Doppler technique and summarize relevant findings of functional Doppler tests in the different vascular territories of the brain. Finally, the concept of a combined functional electroencephalogram and transcranial Doppler technique will be outlined, which allows simultaneous investigation of the neuronal and vascular responses of neurovascular coupling.
神经血管耦合描述了大脑的一种血管调节原理，根据基础神经元活动来调节局部脑血流。它是现代间接脑成像技术的基础。由于其广泛的可用性和高耐受性，功能 transcranial Doppler 已被广泛用于评估临床情况下的脑功能。在本文中，我们将概述目前对耦合的理解，解释多普勒技术的基本原理，并总结功能多普勒测试在大脑不同血管区域的相关发现。最后，将概述联合功能脑电图和 transcranial Doppler 技术的概念，该技术允许同时研究神经血管耦合的神经元和血管反应。
