Department of Neurology, Justus-Liebig University of Giessen, Giessen, Germany.
Cerebrovasc Dis. 2010 Feb;29(3):211-6. doi: 10.1159/000267840.
Due to lacking energy stores, high energy consumption and dependency on a strict aerobic glycolysis, the brain is very dependent on an adequate blood supply of active neurons. Adequate regulation of the functionally induced local cerebral blood flow is assured by neurovascular coupling. Our understanding of its role in different disease processes has improved considerably in the last few years. Consequently, a diagnostic tool is needed which allows an easy and cost-effective investigation of the coupling in clinical conditions. A combined EEG and Doppler technique might be suitable in this regard. This review gives a short overview of the neurophysiological background and the techniques, before validation studies and first clinical applications are addressed.
由于缺乏能量储备、高能耗以及依赖严格的有氧糖酵解，大脑非常依赖活跃神经元的充足血液供应。神经血管耦合可确保功能诱导的局部脑血流得到充分调节。在过去的几年中，我们对其在不同疾病过程中的作用的理解有了很大的提高。因此，需要一种诊断工具，以便在临床条件下轻松且具有成本效益地研究耦合。在解决验证研究和首次临床应用之前，脑电图和多普勒技术的联合应用可能是合适的。本综述简要介绍了神经生理学背景和技术，然后介绍了验证研究和首次临床应用。
