University Children's Hospital Basel, Division of Neuropediatrics and Developmental Medicine, Switzerland.
Epilepsy Behav. 2012 May;24(1):138-40. doi: 10.1016/j.yebeh.2012.03.005. Epub 2012 Apr 12.
We report the case of an adolescent girl who suffered from symptomatic refractory focal epilepsy after an arteria cerebri media insult 15 years prior to this report. Five weeks after initiation of an add-on therapy with vigabatrin, she was seizure free. However, 2 weeks later, she suffered from psychosis. The phenomenon is well known as forced normalization. However, although the medication was stopped immediately, 3 years later, she shows not only persistent mild increased anxiousness, but also a marked reduction of seizure frequency as well as seizure intensity.
我们报告了一例青少年女性病例，该患者在报告前 15 年因大脑中动脉损伤而患有症状性难治性局灶性癫痫。在添加氨己烯酸治疗 5 周后，她无癫痫发作。然而，2 周后，她出现了精神病。这种现象被称为强制性正常化。尽管立即停止了药物治疗，但 3 年后，她不仅持续出现轻度焦虑增加，而且癫痫发作频率和强度也明显降低。
