miRNAs 与雌激素作用。
miRNAs and estrogen action.
机构信息
Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA.
出版信息
Trends Endocrinol Metab. 2012 May;23(5):223-33. doi: 10.1016/j.tem.2012.03.002. Epub 2012 Apr 11.
Abstract
MicroRNAs (miRNAs) are short, noncoding RNAs that generally base-pair within the 3' untranslated region of target mRNAs causing translational inhibition and/or mRNA degradation. Estradiol (E(2)) and other estrogen receptor (ER) ligands suppress or stimulate miRNA expression in human breast cancer cells, endometrial cells, rat mammary gland, and mouse uterus, and post-translationally regulate protein expression. Aberrant miRNA expression is implicated in estrogen-related breast and endometrial cancers, and several miRNAs downregulate ERα. The role of estrogen-regulated miRNA expression, the target genes of these miRNAs, and the role of miRNAs in health and disease is a 'hot' area of research that will yield new insight into molecular mechanisms of estrogen action.
摘要
微小 RNA（miRNA）是短的非编码 RNA，通常在靶 mRNA 的 3'非翻译区与靶 mRNA 碱基配对，导致翻译抑制和/或 mRNA 降解。雌二醇（E2）和其他雌激素受体（ER）配体抑制或刺激人乳腺癌细胞、子宫内膜细胞、大鼠乳腺和小鼠子宫中的 miRNA 表达，并在后翻译水平上调节蛋白表达。miRNA 表达异常与雌激素相关的乳腺癌和子宫内膜癌有关，并且一些 miRNA 下调 ERα。雌激素调节的 miRNA 表达、这些 miRNA 的靶基因以及 miRNA 在健康和疾病中的作用是一个“热门”研究领域，将为雌激素作用的分子机制提供新的见解。
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