Department of Obstetrics and Gynecology, Fengxian Central Hospital, Shanghai 201400, PR China.
Cancer Lett. 2012 Jan 28;314(2):155-65. doi: 10.1016/j.canlet.2011.09.027. Epub 2011 Sep 29.
Uncontrolled estrogen exposure can induce an imbalance in BCL2/BAX expression in endometrial cells, leading to precancerous lesions and type I endometrial adenocarcinoma. This study aimed to explore the mechanism underlying this phenomenon. We show that the activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells. These ER-regulated hsa-let-7 microRNAs can be detected in most hyperplastic endometria, suggesting their potential utility as indicators of estrogen over-exposure.
不受控制的雌激素暴露会导致子宫内膜细胞中 BCL2/BAX 表达失衡，从而导致癌前病变和 I 型子宫内膜腺癌。本研究旨在探讨这种现象的机制。我们发现，激活的雌激素受体可以通过上调一组 microRNAs（包括 hsa-let-7 家族成员和 hsa-miR-27a）来抑制 BAX 的表达，从而促进受影响细胞中 BCL2/BAX 比例的增加以及存活和增殖能力的增强。这些 ER 调节的 hsa-let-7 microRNAs 可以在大多数增生的子宫内膜中检测到，这表明它们可能作为雌激素过度暴露的指标具有潜在的应用价值。
