Psoriatic Arthritis Clinic, Centre for Prognostic Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Toronto Western Research Institute, Toronto, Canada.
Ann Rheum Dis. 2012 Aug;71(8):1370-3. doi: 10.1136/annrheumdis-2011-201208. Epub 2012 Apr 13.
To determine whether there is seasonal variation in disease activity of patients with psoriatic arthritis (PsA).
The authors identified the first available set of consecutive summer and winter visits for every patient from the prospective cohort of PsA. Comparison between summer and winter visits, and comparison of the repeated summer/winter visits, from 1978 until 2011 for the same identified patients was conducted for demographics, disease activity outcomes, laboratory results and treatment. The authors categorised disease activity into high, moderate and low states, and improvement versus flare/worsening. Descriptive statistics were computed and multivariate analyses using logistic regression and generalised estimating equations were conducted.
The first available summer and winter visit were identified for 253 patients, and 1789 observations were analysed. There was no statistically significant difference in patients' demographics, disease activity outcomes, laboratory results and treatment between summer and winter visits. Bath Ankylosing Spondylitis Disease Activity Index scores were greater for summer visits and patients graded their disease as being worse in winter as compared with summer in the univariate analysis, but this difference did not hold in the multivariate analysis.
The change in season does not affect PsA patients' characteristics and disease activity outcomes as determined by the physicians and patients.
确定银屑病关节炎（PsA）患者的疾病活动是否存在季节性变化。
作者从前瞻性 PsA 队列中确定了每位患者首次可获得的夏季和冬季就诊的连续数据集。对 1978 年至 2011 年间同一患者的夏季和冬季就诊进行比较，并对重复的夏季/冬季就诊进行比较，比较内容包括人口统计学特征、疾病活动指标、实验室结果和治疗情况。作者将疾病活动分为高、中、低状态，以及改善与发作/恶化。计算了描述性统计数据，并使用逻辑回归和广义估计方程进行了多变量分析。
确定了 253 名患者的首次可获得的夏季和冬季就诊，共分析了 1789 次就诊。夏季和冬季就诊患者的人口统计学特征、疾病活动指标、实验室结果和治疗情况无统计学差异。夏季就诊时 Bath 强直性脊柱炎疾病活动指数评分较高，且患者在单变量分析中认为冬季疾病比夏季更严重，但在多变量分析中，这种差异并不存在。
季节变化不会影响医生和患者确定的 PsA 患者的特征和疾病活动结果。
