From the Division of Arthritis and Rhumatic Diseases, Oregon Health & Science University and.
J Clin Rheumatol. 2018 Sep;24(6):319-323. doi: 10.1097/RHU.0000000000000630.
Psoriasis Quality of Life (PQoL-12) is a validated composite tool assessing patients' quality of life (QoL) with psoriasis (PsO) and psoriatic arthritis (PsA). Routine Assessment of Patient Index Data 3 (RAPID3), measuring physical function, pain, and patient global assessment, is used for rheumatoid arthritis. Routine Assessment of Patient Index Data 3 has not been used to assess PsO/PsA patients' QoL.
The aim of this study was to investigate the correlation between PQoL-12 and RAPID3 in PsO and PsA patients in a cross-sectional and longitudinal analyses.
Data came from PsO and PsA patients seen from 2008 to 2015 at Oregon Health & Science University (n = 558: 393 with PsO and 165 with PsA). Nonlinear least squares regressions modeled PQoL-12 with functions of RAPID3, controlling for time since first visit. Nonparametric ROC determined RAPID3 scores best correlating with PQoL-12 cutoffs.
Among the PsO cohort, PQoL-12 was explained by RAPID3, the square of RAPID3, time since first visit, and the square of time since first visit; adjusted R = 0.414. For the PsA cohort, PQoL-12 was explained by RAPID3, change in slope of RAPID3 at 2.28, time since first visit, the square of time since first visit; adjusted R = 0.340. Routine Assessment of Patient Index Data 3 cutoffs for PQoL-12 scores of 48 and 96 (mild and moderate QoL impairment) in PsO were 1.55 and 5.72 and in PsA were 1.89 and 6.34.
Routine Assessment of Patient Index Data 3 weakly correlated with PQoL-12, indicating these indices assess different aspects of PsO and PsA. Routine Assessment of Patient Index Data 3 fails to capture mental health information that greatly impacts patients' QoL, whereas PQoL-12 fails to capture the physical and functional aspects of the disease. Results indicate the importance of capturing mental health assessment in order to create a comprehensive tool to measure how psoriatic disease affects patients' QoL.
银屑病生活质量（PQoL-12）是一种经过验证的综合工具，用于评估银屑病（PsO）和银屑病关节炎（PsA）患者的生活质量（QoL）。常规评估患者指数数据 3（RAPID3）用于评估类风湿关节炎，用于测量身体功能、疼痛和患者总体评估。常规评估患者指数数据 3 尚未用于评估 PsO/PsA 患者的 QoL。
本研究旨在通过横断面和纵向分析，研究 PQoL-12 与 PsO 和 PsA 患者 RAPID3 之间的相关性。
数据来自俄勒冈健康与科学大学 2008 年至 2015 年期间就诊的 PsO 和 PsA 患者（n=558：393 例 PsO 和 165 例 PsA）。非线性最小二乘回归模型以 RAPID3 的函数形式对 PQoL-12 进行建模，控制首次就诊后的时间。非参数 ROC 确定了与 PQoL-12 截止值相关性最佳的 RAPID3 评分。
在 PsO 队列中，PQoL-12 由 RAPID3、RAPID3 的平方、首次就诊后的时间和首次就诊后的时间的平方解释；调整后的 R=0.414。对于 PsA 队列，PQoL-12 由 RAPID3、RAPID3 斜率在 2.28 处的变化、首次就诊后的时间、首次就诊后的时间的平方解释；调整后的 R=0.340。PsO 中 PQoL-12 评分为 48 和 96（轻度和中度 QoL 损害）的 RAPID3 截断值分别为 1.55 和 5.72，而 PsA 为 1.89 和 6.34。
常规评估患者指数数据 3 与 PQoL-12 弱相关，表明这些指标评估了 PsO 和 PsA 的不同方面。常规评估患者指数数据 3 无法捕捉对患者 QoL 影响很大的心理健康信息，而 PQoL-12 无法捕捉疾病的身体和功能方面。结果表明，为了创建一个综合工具来衡量银屑病对患者 QoL 的影响，需要评估心理健康。
