Department of Pathology, University of Cambridge, Tennis Court Rd, Cambridge, UK.
Curr Opin Rheumatol. 2012 Jul;24(4):394-400. doi: 10.1097/BOR.0b013e3283535937.
Parasitic worms have evolved strategies to manipulate the host immune system, some of which may lead to a reduction in inflammation. Characterisation of the ways in which these organisms mediate an anti-inflammatory response and identification of parasite-derived molecules involved in immune modulation paves the way to novel therapeutic approaches for the treatment of inflammatory disease. This review highlights recent findings in this field of research in the context of a broader overview.
Some parasites and parasite derived products inhibit inflammatory responses through effects on both the innate and adaptive immune response. Considerable progress has been made in identifying parasite derived molecules, the ways in which they interact with the immune system and how they mediate immunomodulation.
There is great interest in the potential usefulness of parasite-mediated immunomodulation for the treatment and prevention of a range of inflammatory disorders. Much remains to be resolved regarding characterisation of potential helminth-derived biomodulators, timing and dose of exposure to the agents as well as characterisation of the modes of action so that synthetic analogues that mimic the effects can be generated.
寄生虫已经进化出了操纵宿主免疫系统的策略，其中一些策略可能会导致炎症减轻。这些生物体介导抗炎反应的方式的特征，以及参与免疫调节的寄生虫衍生分子的鉴定，为炎症性疾病的治疗开辟了新的治疗方法。本综述在更广泛的概述背景下，强调了该研究领域的最新发现。
一些寄生虫和寄生虫衍生产物通过对先天和适应性免疫反应的影响来抑制炎症反应。在鉴定寄生虫衍生分子、它们与免疫系统相互作用的方式以及它们介导免疫调节的方式方面已经取得了相当大的进展。
人们对寄生虫介导的免疫调节在治疗和预防一系列炎症性疾病方面的潜在用途非常感兴趣。在鉴定潜在的蠕虫衍生生物调节剂、暴露于这些药物的时间和剂量以及作用方式的特征方面，还有很多问题需要解决，以便生成模拟这些效果的合成类似物。
