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骨质疏松症和低骨量:对牙周病和种植治疗的影响。

Osteoporosis and osteopenia: implications for periodontal and implant therapy.

出版信息

Periodontol 2000. 2012 Jun;59(1):111-39. doi: 10.1111/j.1600-0757.2011.00435.x.

Abstract

How does low bone mineral density alter treatment decisions? Osteoporosis and osteopenia are major health care issues that may impact on periodontal and implant therapy. Because of the prevalence of osteoporosis, understanding its etiology and the current treatment regimens for patients with low bone mineral density is essential for dental professionals. Millions of patients are now taking medications for the treatment of osteoporosis, and periodontists should be aware of the many medication options that are prescribed. The most frequently prescribed drugs are the bisphosphonates. It is important to be aware that bisphosphonates are not all the same, and patient responses to treatment may vary depending on which bisphosphonates they are taking. Due to recent concerns about bisphosphonate-induced osteonecrosis of the jaw, this paper provides guidance to help the clinician regarding decision-making about preventive and interventional dental treatment when their patient has been prescribed a bisphosphonate. An understanding of current bisphosphonates, their uses, their structural differences and their intended actions helps to improve clinical decision-making. Current knowledge regarding the effects of osteoporosis/osteopenia on periodontal diseases and alveolar bone loss is inconclusive. It is certainly clear that bisphosphonates are not indicated as an adjunctive treatment as part of periodontal therapy because of the risk of osteonecrosis. Regarding implant placement, there are no convincing data that dental implant placement is contraindicated in the osteoporotic patient. However, patients should understand the small risk of compromised bone healing following implant placement if the patient has been taking bisphosphonates. Due to the risks of osteonecrosis, dental clinicians should work closely with their medical colleagues prior to the physician prescribing oral bisphosphonates. Ideally, optimal periodontal and dental health should be established before the patient commences bisphosphonate therapy.

摘要

低骨密度如何改变治疗决策?骨质疏松症和骨量减少是主要的健康问题,可能会影响牙周病和种植治疗。由于骨质疏松症的患病率,了解其病因和目前治疗低骨密度患者的方案对于牙科专业人员至关重要。现在有数百万患者正在服用骨质疏松症药物,牙周病医生应该了解许多规定的药物选择。最常开的药物是双膦酸盐。重要的是要意识到,双膦酸盐并不完全相同,患者对治疗的反应可能因他们服用的双膦酸盐而异。由于最近对双膦酸盐引起的下颌骨坏死的担忧,本文为临床医生提供了指导,帮助他们在为服用双膦酸盐的患者制定预防性和介入性牙科治疗决策时做出决策。了解当前的双膦酸盐、它们的用途、它们的结构差异及其预期作用有助于改善临床决策。关于骨质疏松症/骨量减少对牙周病和牙槽骨丧失的影响,目前的知识尚无定论。可以肯定的是,由于存在骨坏死的风险,双膦酸盐不适合作为牙周病治疗的辅助治疗。关于种植体放置,没有令人信服的数据表明骨质疏松症患者不能进行种植体放置。然而,如果患者服用了双膦酸盐,患者应该了解在种植体放置后骨愈合受损的小风险。由于骨坏死的风险,牙科临床医生应在医生开出口服双膦酸盐之前与他们的医疗同事密切合作。理想情况下,在患者开始双膦酸盐治疗之前,应先建立最佳的牙周和口腔健康。

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