Department of Oral Sciences, Nano and Biotechnology, University G. d'Annunzio, Chieti, Italy.
Int J Immunopathol Pharmacol. 2012 Jan-Mar;25(1):157-63. doi: 10.1177/039463201202500118.
The aim of this work is to verify a correlation between the grade of inflammation and the concentration of PGE2 in human dental pulp. A total of 25 human dental pulps were examined by histological analysis and radioimmunologic dosage of PGE2. The pulps used in this experiment were from healthy and symptomatic teeth; the first ones were collected from teeth destined to be extracted for orthodontic reasons. An increase was observed of PGE2 in reversible pulpitis compared with healthy pulps and with the irreversible pulpitis and the clear decrease of these when NSAIDs are taken. This study demonstrates that PGE2 level is correlated to histological analysis thus allowing to distinguish symptomatic teeth in reversible and irreversible pulpitis.
本研究旨在验证人牙髓炎症程度与 PGE2 浓度之间的相关性。通过组织学分析和 PGE2 的放射免疫定量检测，共检查了 25 个人类牙髓。本实验中使用的牙髓来自健康和有症状的牙齿；前者是从因正畸原因而要拔出的牙齿中收集的。与健康牙髓和不可逆性牙髓炎相比，可逆性牙髓炎中 PGE2 增加，而当使用 NSAIDs 时则明显减少。本研究表明，PGE2 水平与组织学分析相关，因此可以区分可逆性和不可逆性牙髓炎中的有症状牙齿。
