Shahin Zeinab, Leheta Tahra M, Abdel Hay Rania M, Abdel Aal Hanaa M, Rashed Laila A
Dermatology Department, Faculty of Medicine, Cairo University, Egypt.
Acta Dermatovenerol Croat. 2012;20(1):14-20.
Vitiligo is one of the most troubling diseases to both patient and physician. Monoamines are chemical compounds derived from the hydroxyderivative of amino acids. They have been implicated in many dermatoses, but their role in the etiopathogenesis of vitiligo remains obscure. The aim of the study was to evaluate the role of the neural factor in the pathogenesis of nonsegmental vitiligo (NSV) by measuring catecholamines and their metabolites in plasma and urine of patients suffering from NSV, and to correlate these factors with the onset and activity of the disease. The study included 20 patients with NSV and 20 healthy individuals. All subjects were subjected to plasma and urine detection of catecholamines and 5-hydroxyindoleacetic acid (5-HIAA) using high-performance liquid chromatography and electrochemical detection. Comparison of plasma and urinary catecholamines and 5-HIAA between the patient and control groups revealed a statistically significant increase in the group of NSV patients (P<0.05). There was no statistically significant difference (P>0.05) between the patients with recent and old onset of NSV. In conclusion, the increase in the level of monoamines may be the initiating event in the pathogenesis of NSV.
白癜风是患者和医生都最为困扰的疾病之一。单胺是由氨基酸的羟基衍生物衍生而来的化合物。它们与许多皮肤病有关，但其在白癜风发病机制中的作用仍不清楚。本研究的目的是通过测量非节段性白癜风（NSV）患者血浆和尿液中的儿茶酚胺及其代谢产物，评估神经因素在NSV发病机制中的作用，并将这些因素与疾病的发作和活动相关联。该研究包括20例NSV患者和20名健康个体。所有受试者均采用高效液相色谱法和电化学检测法对血浆和尿液中的儿茶酚胺和5-羟吲哚乙酸（5-HIAA）进行检测。患者组和对照组之间血浆和尿儿茶酚胺及5-HIAA的比较显示，NSV患者组有统计学意义的升高（P<0.05）。NSV近期发病和陈旧发病患者之间无统计学意义的差异（P>0.05）。总之，单胺水平的升高可能是NSV发病机制中的起始事件。
