Center for Family and Community Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Am J Hum Biol. 2012 Sep-Oct;24(5):595-601. doi: 10.1002/ajhb.22279. Epub 2012 Apr 17.
In view of the increasing prevalence of obesity worldwide, understanding the role of the recently discovered adipokines leptin and adiponectin is of high clinical relevance. The aim of the present study was to assess the association between levels of leptin and adiponectin with age, known cardiovascular risk factors and to establish whether there are differences between men and women of the general population.
A total of 98 men and 107 women of the general population, aged between 20 and 74 years, underwent a medical examination at a clinical research center and fasting morning blood samples were also taken.
Leptin (mean 7.5 μg l(-1) in men and 16.0 μg l(-1) in women) and adiponectin (mean 7.3 mg l(-1) in men and 11.9 mg l(-1) in women) levels were higher in women than men (Ps < 0.001). Both leptin and adiponectin levels increased with advancing age in both men and women (Ps < 0.05). Leptin was highly associated with factors for metabolic syndrome in men while in women, leptin was highly associated with inflammatory factors. Adiponectin was associated with blood lipids in both men and women, and glucose homeostasis more in women than in men.
Leptin and adiponectin levels were ∼2 times and 1.5 times higher in women than in men, respectively. In addition, although leptin and adiponectin were associated to CVD risk factors in both men and women, we observed differences in specific CVD risk factor groups between men and women. These differences may be due to different regulatory mechanisms and effects of these adipokines in men and women.
鉴于全球肥胖症的发病率不断上升，了解最近发现的脂肪因子瘦素和脂联素的作用具有重要的临床意义。本研究旨在评估瘦素和脂联素水平与年龄、已知心血管危险因素的关系，并确定普通人群中男女之间是否存在差异。
共有 98 名男性和 107 名年龄在 20 至 74 岁之间的普通人群在临床研究中心接受了体检，并采集了空腹晨血样。
女性的瘦素（男性平均为 7.5 μg/L，女性为 16.0 μg/L）和脂联素（男性平均为 7.3 mg/L，女性为 11.9 mg/L）水平高于男性（P<0.001）。男性和女性的瘦素和脂联素水平均随年龄增长而增加（P<0.05）。男性的瘦素与代谢综合征的相关因素高度相关，而女性的瘦素与炎症因子高度相关。脂联素与男性和女性的血脂相关，而在女性中与血糖稳态的相关性高于男性。
女性的瘦素和脂联素水平分别比男性高约 2 倍和 1.5 倍。此外，尽管瘦素和脂联素与男性和女性的心血管危险因素相关，但我们观察到男女之间特定心血管危险因素组之间存在差异。这些差异可能是由于这些脂肪因子在男性和女性中的不同调节机制和作用所致。
