在台湾老年人中，血清瘦素水平与代谢综合征呈正相关。
Serum leptin level positively correlates with metabolic syndrome among elderly Taiwanese.
作者信息
Wang Li-Hsuan, Liu Yao-Chang, Wang Ji-Hung, Lee Chung-Jen, Hsu Bang-Gee
机构信息
School of Medicine, Tzu Chi University, Hualien, Taiwan.
Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
出版信息
Tzu Chi Med J. 2017 Jul-Sep;29(3):159-164. doi: 10.4103/tcmj.tcmj_60_17.
OBJECTIVE
Leptin is an adipocyte-derived hormone and has shown positive correlation with obesity and metabolic syndrome (MetS) in many studies. However, there are few studies investigating this relation in elderly people. Therefore, we aimed to investigate the correlation between the fasting serum leptin level and MetS among older Taiwanese.
MATERIALS AND METHODS
The fasting serum leptin level was obtained from 62 Taiwanese participants over 65 years old and was measured using a commercially available enzyme immunoassay kit. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation.
RESULTS
Thirty elderly participants (48.4%) had MetS. The serum leptin level was positively correlated with MetS ( < 0.001). Multivariate logistic regression analysis of the factors significantly associated with MetS showed that logarithmically transformed leptin (log-leptin, each increase 0.1 ng/mL log-leptin, odds ratio: 1.276, 95% confidence interval: 1.015-1.603, = 0.037) was still an independent predictor of MetS in elderly persons. Univariable linear analysis showed that body weight ( = 0280, = 0.028), body mass index ( = 0.417, = 0.001), waist circumference ( = 0.419, = 0.001), blood urea nitrogen ( = 0255, = 0.046), log-insulin ( = 0436, < 0.001), and logarithmically transformed homeostasis model assessment of insulin resistance ( = 0359, = 0.004) positively correlated with fasting serum log-leptin levels. Multivariate forward stepwise linear regression analysis of the factors significantly associated with fasting serum log-leptin levels revealed that waist circumference (adjusted = 0.083, = 0.002), statin use (adjusted = 0.058, = 0.016), and female gender (adjusted = 0.041, = 0.034) were independent predictors of fasting serum log-leptin levels among elderly participants.
CONCLUSION
In elderly Taiwanese, the serum leptin level was positively correlated with MetS. Waist circumference, statin use, and female gender were independent predictors of the fasting serum leptin level in elderly participants.
目的
瘦素是一种由脂肪细胞分泌的激素，许多研究表明其与肥胖和代谢综合征（MetS）呈正相关。然而，针对老年人中这种关系的研究较少。因此，我们旨在调查台湾老年人群空腹血清瘦素水平与代谢综合征之间的相关性。
材料与方法
从62名65岁以上的台湾参与者中获取空腹血清瘦素水平，并使用市售酶免疫分析试剂盒进行测量。代谢综合征及其组分依据国际糖尿病联盟的诊断标准来定义。
结果
30名老年参与者（48.4%）患有代谢综合征。血清瘦素水平与代谢综合征呈正相关（<0.001）。对与代谢综合征显著相关的因素进行多因素逻辑回归分析显示，对数转换后的瘦素（log-瘦素，每增加0.1 ng/mL log-瘦素，比值比：1.276，95%置信区间：1.015 - 1.603， = 0.037）仍是老年人代谢综合征的独立预测因子。单变量线性分析表明，体重（ = 0280， = 0.028）、体重指数（ = 0.417， = 0.001）、腰围（ = 0.419， = 0.001）、血尿素氮（ = 0255， = 0.046）、log-胰岛素（ = 0436， < 0.001）以及对数转换后的胰岛素抵抗稳态模型评估（ = 0359， = 0.004）与空腹血清log-瘦素水平呈正相关。对与空腹血清log-瘦素水平显著相关的因素进行多变量向前逐步线性回归分析显示，腰围（调整后 = 0.083， = 0.002）、他汀类药物使用（调整后 = 0.058， = 0.016）以及女性性别（调整后 = 0.041， = 0.034）是老年参与者空腹血清log-瘦素水平的独立预测因子。
结论
在台湾老年人中，血清瘦素水平与代谢综合征呈正相关。腰围、他汀类药物使用以及女性性别是老年参与者空腹血清瘦素水平的独立预测因子。
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