神经影像学：在检测前驱期帕金森病中的当前作用。

Neuroimaging: current role in detecting pre-motor Parkinson's disease.

机构信息

Center of Neurology, Hertie Institute for Clinical Brain Research, Department of Neurodegeneration and German Center of Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany.

出版信息

Mov Disord. 2012 Apr 15;27(5):634-43. doi: 10.1002/mds.24976.

DOI:10.1002/mds.24976

PMID:22508281

Abstract

Convergent evidence suggests a pre-motor period in Parkinson's disease (PD) during which typical motor symptoms have not yet developed although dopaminergic neurons in the substantia nigra have started to degenerate. Advances in different neuroimaging techniques have allowed the detection of functional and structural changes in early PD. This review summarizes the state of the art knowledge concerning structural neuroimaging techniques including magnetic resonance imaging (MRI) and transcranial B-mode-Doppler-sonography (TCS) as well as functional neuroimaging techniques using radiotracer imaging (RTI) with different radioligands in detecting pre-motor PD.

摘要

已有研究表明，在帕金森病（PD）中存在一个前驱期，此时典型的运动症状尚未出现，但黑质中的多巴胺能神经元已经开始退化。不同神经影像学技术的进步使得人们能够在早期 PD 中检测到功能和结构变化。本文综述了磁共振成像（MRI）和经颅 B 型超声多普勒（TCS）等结构神经影像学技术，以及使用不同示踪剂的放射性配体示踪成像（RTI）等功能神经影像学技术，用于探测前驱期 PD 的研究现状。