Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Functional Neuroimaging Research, National Institute of Radiological Sciences, Chiba, Japan.
Sci Rep. 2017 Aug 14;7(1):8019. doi: 10.1038/s41598-017-08482-0.
Deficits in the integration of motor prediction and its feedback have been reported in Parkinson's disease. Conscious awareness of action is proposed to emerge under the integration of motor prediction and its feedback. Thus, it may lead to changes in the awareness of the authorship of action (in other words, the sense of agency) in Parkinson's disease. We have employed both explicit and implicit measures to assess the awareness of action in Parkinson's disease and matched controls. As an explicit measure, an action recognition task requiring explicit judgments was used. Patients showed less attribution of their movements to non-biased and angular-biased visual feedbacks. As an implicit measure, the temporal attraction between the perceived time of actions and their effects, which is known as intentional binding task, was used. While action-effect association was observed in the control group, actions were not experienced as having shifted towards their subsequent effects in the patient group. These tendencies were consistent regardless of the side of the asymmetrical motor symptoms. These results may reflect an underlying abnormality in the awareness of voluntary action in Parkinson's disease.
运动预测及其反馈的整合缺陷在帕金森病中已有报道。运动预测及其反馈的整合被认为是意识产生的基础。因此，这可能导致帕金森病患者对动作作者身份（换句话说，就是代理感）的意识发生变化。我们使用了显性和隐性测量来评估帕金森病患者和匹配对照组的动作意识。作为一种显性测量，使用了需要显性判断的动作识别任务。患者对非偏向性和角度偏向性视觉反馈的运动归因较少。作为一种隐性测量，使用了感知动作时间和动作效果之间的时间吸引力，即意图绑定任务。虽然在对照组中观察到了动作-效果关联，但在患者组中，动作并没有被体验为向随后的效果移动。这些趋势与不对称运动症状的侧别无关。这些结果可能反映了帕金森病患者对自愿动作的意识存在潜在异常。
