Harp Eric, Caraway Nancy P
Department of Pathology, College Station Medical Center, Bryan, Texas.
Diagn Cytopathol. 2013 Sep;41(9):825-8. doi: 10.1002/dc.22851. Epub 2012 Apr 17.
Granular cell tumor rarely occurs in the thyroid. This case report describes the cytologic features of a granular cell tumor seen in a fine needle aspirate obtained from a 27-year-old woman with a gradually enlarging thyroid nodule. The aspirate showed single as well as syncytial clusters of cells with abundant granular cytoplasm. The differential diagnosis in this case included granular cell tumor, Hurthle cell lesion/neoplasm, and a histiocytic reparative process. Immunohistochemical studies, including S-100 protein and CD68, performed on a cell block preparation were helpful in supporting the diagnosis.
颗粒细胞瘤很少发生于甲状腺。本病例报告描述了一名27岁女性甲状腺结节逐渐增大，经细针穿刺吸取物中所见颗粒细胞瘤的细胞学特征。吸取物显示单个及合体细胞团，胞质丰富且呈颗粒状。该病例的鉴别诊断包括颗粒细胞瘤、许特耳细胞病变/肿瘤以及组织细胞修复过程。在细胞块标本上进行的免疫组织化学研究，包括S-100蛋白和CD68检测，有助于支持诊断。
