复发性甲状腺颗粒细胞瘤：一例报告及文献复习
Recurrent granular cell tumor of the thyroid: a case report and literature review.
作者信息
He Yu-Qin, Lu Hai-Zhen, Li De-Zhi, Chen Mo-Qi, Wang Kai, Xu Zhen-Gang, Liu Shao-Yan
机构信息
National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
出版信息
BMC Surg. 2020 Jul 14;20(1):154. doi: 10.1186/s12893-020-00814-8.
BACKGROUND
Granular cell tumor (GCT) of the thyroid is a rare benign tumor of Schwann cell origin with a favorable prognosis and only 10 cases have been reported so far in scientific literature. The present case study describes the first case of recurrent thyroid GCT.
CASE PRESENTATION
Our case describes a 20-year-old woman who had undergone lobectomy for GCT of the thyroid 4 years ago. Hematoxylin-eosin (HE) staining revealed that the lesion was composed of epithelioid cells with an abundance of eosinophilic granular cytoplasm. Immunohistochemical analysis showed that tumor cells tested positive for S-100 protein and negative for desmin. Both histological and immunohistochemical analyses supported the diagnosis of recurrent GCT of the thyroid.
CONCLUSIONS
Our case suggested that a tumor-free margin excision and post-operative follow-up are necessary for the treatment of GCT of the thyroid.
背景
甲状腺颗粒细胞瘤（GCT）是一种罕见的起源于施万细胞的良性肿瘤，预后良好，迄今为止科学文献中仅报道了10例。本病例研究描述了首例复发性甲状腺GCT。
病例介绍
我们的病例是一名20岁女性，4年前因甲状腺GCT接受了叶切除术。苏木精-伊红（HE）染色显示病变由具有丰富嗜酸性颗粒细胞质的上皮样细胞组成。免疫组织化学分析显示肿瘤细胞S-100蛋白检测呈阳性，结蛋白检测呈阴性。组织学和免疫组织化学分析均支持复发性甲状腺GCT的诊断。
结论
我们的病例表明，甲状腺GCT的治疗需要切缘无肿瘤切除及术后随访。
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