Chang Shu-Mei, Wei Chang-Kuo, Tseng Chih-En
Department of Anatomic Pathology, Buddhist Dalin Tzu Chi General Hospital, 2, Min-Sheng Rd Dalin Town, Chiayi, Taiwan.
Endocr Pathol. 2009 Summer;20(2):137-40. doi: 10.1007/s12022-009-9071-5.
Granular cell tumor (GCT) of the thyroid is rare. Before this report, only four cases of thyroid GCT have been reported, none of which presented a cytopathological examination. In this paper, we report the fine needle aspiration cytology and pathological analysis of a thyroid GCT from a 12-year-old girl who presented with a painless neck mass. The tumor cells were single, in syncytial clusters, or pseudofollicles, contained small round, oval, or spindle nuclei, indistinct nucleoli, and a large amount of grayish, granular fragile cytoplasm. The background contained granular debris and naked nuclei. A differential diagnosis of thyroid GCT with more frequent thyroid lesions containing cytoplasmic granules, including Hurthle cells, macrophages, follicular cells, and cells of black thyroid syndrome, was also performed.
甲状腺颗粒细胞瘤（GCT）较为罕见。在本报告之前，仅报道过4例甲状腺GCT，均未进行细胞病理学检查。本文报告了1例12岁女孩甲状腺GCT的细针穿刺细胞学及病理分析，该女孩表现为无痛性颈部肿块。肿瘤细胞呈单个、合体细胞团或假滤泡状，核小而圆、椭圆形或梭形，核仁不明显，胞质丰富、灰染、呈颗粒状且易碎。背景中可见颗粒状碎屑及裸核。还对甲状腺GCT与更常见的含细胞质颗粒的甲状腺病变进行了鉴别诊断，这些病变包括许特莱细胞、巨噬细胞、滤泡细胞及黑色甲状腺综合征的细胞。
