Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructures and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: (+86) 1062561085.
Chem Asian J. 2013 Oct;8(10):2370-6. doi: 10.1002/asia.201300039. Epub 2013 Jun 12.
Fullerene-based photosensitizers exhibit great potential in photodynamic therapy (PDT). Based on the high photodynamic efficacy of trimalonic acid-modified C70 fullerene (TF70), we constructed an aptamer-guided TF70 photosensitizer and investigated its photodynamic effect. Conjugation of the novel aptamer (named R13) could effectively enhance the PDT efficiency of TF70 against A549 lung cancer cells in the presence of serum. The lysosomal location of the TF70-R13 conjugate inside cells facilitates the production of intracellular reactive oxygen species (ROS), which can efficiently kill cells, under light irradiation. The enhanced photodynamic efficiency, along with its good biocompatibility in the dark, makes TF70-R13 a highly promising photosensitizer for tumor-specific PDT.
富勒烯基光敏剂在光动力疗法（PDT）中具有巨大的潜力。基于三戊二酸修饰的 C70 富勒烯（TF70）的高光动力疗效，我们构建了一种适体引导的 TF70 光敏剂，并研究了其光动力效应。新型适体（命名为 R13）的缀合可以有效地提高 TF70 在血清存在下对 A549 肺癌细胞的 PDT 效率。在光照射下，TF70-R13 缀合物在细胞内的溶酶体位置有利于产生细胞内活性氧（ROS），从而有效地杀死细胞。增强的光动力效率，以及其在黑暗中的良好生物相容性，使 TF70-R13 成为一种很有前途的用于肿瘤特异性 PDT 的光敏剂。
